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Protein Overview: SEC15

General Information:
Name(s) found: SEC15 / YGL233W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 910 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IPILink to PubMed article]
    exocyst [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    vesicle docking during exocytosis [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQEGQPLLS KDFQQVLLAT ASGNNSSWTE RAVLNNESTD AVKHEPALGQ NDVFDLDPLS  60
   61 FDKWVPFLRR ALDKNQLDPV IDELENSIED NFQGLELQLL QDSQMNDKLE TSIDEIANIQ 120
  121 GMVQDTLSSE ISKFQIRLSE SANELIVKKQ MYVNNKKISL KISEATILIT KVVRILELSS 180
  181 KCQELITERK FFKVLQNLDS LEKLYLQEFK NYNFQFLIEI YNSIPFLQKV TKDECINLIR 240
  241 NSLNLNLGKN LIKVGQEFVA IYENELLPQW LETRSKMKLT NFKFNSPIEI SMRDESFLAK 300
  301 LNLGEFFQLD DFHDSIMIFQ NLNELSVLSG EFNKEYELRK TKLMYPLIWK KNKTAAYQMD 360
  361 SLLRGTGTTP GSTAHDVSTD DPFTQSLSLH FLQDYFLKIL GFLLYDINLN KATEFILVDN 420
  421 NYNSTNEFWD GLMDRLSPYL SYFIDEKLKT EEDMIKLKDF LCIYVAILEN FKLNIEPLYK 480
  481 ILVSIFEKFC SVSLRAFDDE FQILLNDDDF MPLSINDKTL YEKVLKICWM KEGEHLSLPD 540
  541 PTNGEPFAVT LPFSPLYPMT CTLAKKTYSK ITAFLSIFYR HELHTLNNIL VKTMDDIFND 600
  601 IVNKKIRSKL ESTSREEIAQ ILVNLDYFII AAKEFSNFMT RENILQNPDM EIRLSSIKYL 660
  661 AESRKLAETK LIELIDSKIS DILETIEIDW QITEVRQDPD ISIIDLAQFL EMMFASTLQN 720
  721 LPYSVQTLLI FREFDSLTRQ FMGLLLHDTP STITHESIMN FEVDVNYLES IIPRIFPSTP 780
  781 GTIDSNGYQS PMTPSTPTFP NANGVDAPTL FENNIKSLEA TFMELKQCIE LLKTQGKDYN 840
  841 EPEIRLRKYS RIRQEDAALL LSKIQHFVSS VEGANGDDTS VMDSSSIFNS ESASVIDSNT 900
  901 SRIAKFFNRR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EXO84 SEC15 SEC3
    View Details (MIPS) Mewes HW, et al. (2004) EXO70 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
    View Details Qiu et al. (2008) EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PAC1 SEC15 2 Unpublished Fields Lab Data
    View Screen EXO84 SEC15 2 Drees BL, et al. (2001)
    View Screen BEM1 SEC15 2 Drees BL, et al. (2001)
    View Screen STE50 SEC15 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC15 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] ORFEUS 7.11 Proapoptotic molecule Bid
    2 View Details [77..291] ORFEUS 8.45 Apolipoprotein A-I
    3 View Details [292..379] deduced N/A No confident structure predictions are available.
    4 View Details [380..550]
    [624..667]
    [721..730]    		 ORFEUS 7.65 Histidine ammonia-lyase (HAL)
    5 View Details [551..623]
    [668..720]
    [731..775]    		 ORFEUS 7.65 Histidine ammonia-lyase (HAL)
    6 View Details [776..910] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle