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Protein Overview: SEC5

General Information:
Name(s) found: SEC5 / YDR166C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 971 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    exocyst [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    vesicle docking during exocytosis [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: protein binding [IGILink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRFQIGDEQ LLRFYQLKTI NPTHSWAQDS SKLNNEEATS NELGVETSFD ILKDFKYGNQ  60
   61 ISIDKESRAY LNDESLSYIR DPLNGQEMSK ELQHLPNDSM RLNYLVNSKQ FNVKAFLRDM 120
  121 HKQDSFNDLN NSLDRLDSDI QDQSIHLKQL VGKNFTKYVK IKNKLDQIYK EFDEKTNEKN 180
  181 QCDSPKENQI NVESLNKKVD EVIRTTTFKL KPLMDNYQKI LNYQATKKFI ELNKFYFNLP 240
  241 KSLKRCLTNN DFNEFIIEYS KGLTLRRRFN QSSDASQSLV IKRIWTQIEN LLVTYKDLIW 300
  301 NSLINSNFNI DQPQETILSL FSKLLNLENF INNNQRESES GNKNTTSSSN ENPILRWMSI 360
  361 KMNGFQNELN ELSGHMISKI IHSQRLILQN NTNQDKSQGC VELSYYLKIN QLFQIISDTG 420
  421 KDSEGLKSTV EPNKVNTISG TSYLNLNCQP SSQGLTDSPT IIEMWLLILK YINDLWKICD 480
  481 QFIEFWEHIE KFLDGTYQNS IINEKRKENI LIGDSNIIES YQKSLILKEE QINEVRLKGE 540
  541 EFITSVSQNL ISFFTSSQSS LPSSLKDSTG DITRSNKDSG SPLDYGFIPP NCNGLSCLRY 600
  601 LPKIVEPILK FSTELAQLNI TTNGITICRN TLSTIINRCV GAISSTKLRD ISNFYQLENW 660
  661 QVYETVTFSS KSQDSSKNLT FEYGVTQFPE IVTSFQEVSI KTTRDLLFAY EKLPIINGIS 720
  721 VVSYPSKQLL TGIEIQQIIS MEAVLEAILK NAAKDKDNPR NSHTILTLTN LQYFRECAFP 780
  781 NILQYFDDAF EWNLASKNLE LFSLLSKMES SIFGNYLSDL KINLRDTLEE KFHEINWPMY 840
  841 TSNSFRVGDY IIEALMILIV VHSECFRIGP QLIHKILIET QIFIARYLFE AFKPYVGNLS 900
  901 NDGSLQIIVD LEFFQKVMGP LLEKDTEATL RACLQNCFQN DTNRLQKCIN EINPIVSANL 960
  961 KRTAIQFAAF S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details (MIPS) Mewes HW, et al. (2004) EXO70 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
    View Details Krogan NJ, et al. (2006) SEC5 YDR266C YPR114W
    View Details Gavin AC, et al. (2006) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details Gavin AC, et al. (2002) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8 VPS9
    View Details Qiu et al. (2008) EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [87..162] MSA 5.020992 View MSA. No confident structure predictions are available.
    3 View Details [163..392] MSA 1.016971 View MSA. No confident structure predictions are available.
    4 View Details [393..532] deduced N/A No confident structure predictions are available.
    5 View Details [533..671] MSA 1.006992 View MSA. No confident structure predictions are available.
    6 View Details [672..725] deduced N/A No confident structure predictions are available.
    7 View Details [726..971] MSA 1.006942 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle