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Protein Overview: EXO70

General Information:
Name(s) found: EXO70 / YJL085W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 623 amino acids

    Gene Ontology:
    Cellular Component: exocyst [IPILink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    vesicle docking during exocytosis [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAEIDIDEA DVLVLSQELQ KTSKLTFEIN KSLKKIAATS NQSSQLFTPI LARNNVLTTL  60
   61 QRNIESTLNS VASVKDLANE ASKYEIILQK GINQVGLKQY TQVVHKLDDM LEDIQSGQAN 120
  121 REENSEFHGI LTHLEQLIKR SEAQLRVYFI SILNSIKPFD PQINITKKMP FPYYEDQQLG 180
  181 ALSWILDYFH GNSEGSIIQD ILVGERSKLI LKCMAFLEPF AKEISTAKNA PYEKGSSGMN 240
  241 SYTEALLGFI ANEKSLVDDL YSQYTESKPH VLSQILSPLI SAYAKLFGAN LKIVRSNLEN 300
  301 FGFFSFELVE SINDVKKSLR GKELQNYNLL QDCTQEVRQV TQSLFRDAID RIIKKANSIS 360
  361 TIPSNNGVTE ATVDTMSRLR KFSEYKNGCL GAMDNITREN WLPSNYKEKE YTLQNEALNW 420
  421 EDHNVLLSCF ISDCIDTLAV NLERKAQIAL MPNQEPDVAN PNSSKNKHKQ RIGFFILMNL 480
  481 TLVEQIVEKS ELNLMLAGEG HSRLERLKKR YISYMVSDWR DLTANLMDSV FIDSSGKKSK 540
  541 DKEQIKEKFR KFNEGFEDLV SKTKQYKLSD PSLKVTLKSE IISLVMPMYE RFYSRYKDSF 600
  601 KNPRKHIKYT PDELTTVLNQ LVR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) EXO70 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
    View Details Ho Y, et al. (2002) CIN5 EXO70 HHF1, HHF2 HTA1 IRC20
    View Details Qiu et al. (2008) EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data EXO70 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] ORFEUS 8.48 alpha-actinin
    2 View Details [217..533] MSA 1.038953 View MSA. No confident structure predictions are available.
    3 View Details [534..623] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle