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Protein Overview: YDR266C

General Information:
Name(s) found: YDR266C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 639 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESVKENVT PTRNFRRTQG PQNNTKPHND RKNFRRKQKK NNLSAEPNLT TSSADDTDEE  60
   61 NELCVICARK LTYVSLTPCH HKTCHICGFR QRALYNKKSC LICRTENEEV MFTDRIDGDI 120
  121 SDKYNFCEKN EKYGINFTSE EVATETLNLL KFFCPLSKDE QVCDFGSFKK YNEHLKSEHN 180
  181 RMICLICATH KHAFPCELEI FTQNQLRNHQ TKGNSEGFKG HPMCAFCSGK RFYSDDELYI 240
  241 HMRNQHEKCH ICDKMNPASP QYFKDYNQLF DHFKHSHYVC TVQTCLDNKF VVFKDELELQ 300
  301 AHILQEHGNI LKGKPKFFQS ELSTFISAPS RVIRERDDYD LPSISSLPGS SSGSRTDVRS 360
  361 ASSPEESRLR LAERAKYYLE NSKEDFNKFS SYNEDYSKGR LSAEKLLESY KLLFTKPNAD 420
  421 VYLLIHNLAE TFPKNSSKYN NLNAIYEQRE QTLARQTSLP SLSSDSSLSM SIGRGHWGGT 480
  481 NDGGSAGAAL GVRNIKNLPT LKSPSASYDP FATTVKKNTL RPVQNIKRTT PQSVSYRTST 540
  541 NTVAFSPTYL ESKKGSSSTS LNNSKDKLKS LNLPQLPPPK PKVQIPGLNR PQIADPKQWG 600
  601 KKSSTQDTNV HDNLRELNTT SGGNKKKGKQ KQLLFHIGV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SEC5 YDR266C YPR114W
    View Details Ho Y, et al. (2002) CLU1 MGE1 YDR266C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YDR266C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] PSI-BLAST 25.0 Designed zinc finger protein
    2 View Details [182..269] PSI-BLAST 15.69897 Five-finger GLI1
    3 View Details [270..347] PSI-BLAST 15.69897 Five-finger GLI1
    4 View Details [348..473] PSI-BLAST 9.221849 ZIF268
    5 View Details [474..639] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.56793851778364 bayes_pls_golite062009
  • DNA binding
    		•  3.54020314355238 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.5199046417859 bayes_pls_golite062009
  • binding
    		•  2.67810465561307 bayes_pls_golite062009
  • transcription factor activity
    		•  2.55187755119308 bayes_pls_golite062009
  • transcription activator activity
    		•  1.42994934871119 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.39866271783743 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • RNA binding
    		•  0.938541269618281 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.929401148394889 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.72547620392762 bayes_pls_golite062009
  • transcription factor binding
    		•  0.70656389852666 bayes_pls_golite062009
  • chromatin binding
    		•  0.67474205629207 bayes_pls_golite062009
  • mRNA binding
    		•  0.529908848614478 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.26938915748667 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0675941993292299 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle