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Protein Overview: PEP12

General Information:
Name(s) found: PEP12 / YOR036W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 288 amino acids

    Gene Ontology:
    Cellular Component: endosome [IMPLink to PubMed article]
    Golgi apparatus [IMPLink to PubMed article]
    Biological Process: Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEDEFFGGD NEAVWNGSRF SDSPEFQTLK EEVAAELFEI NGQISTLQQF TATLKSFIDR  60
   61 GDVSAKVVER INKRSVAKIE EIGGLIKKVN TSVKKMDAIE EASLDKTQII AREKLVRDVS 120
  121 YSFQEFQGIQ RQFTQVMKQV NERAKESLEA SEMANDAALL DEEQRQNSSK STRIPGSQIV 180
  181 IERDPINNEE FAYQQNLIEQ RDQEISNIER GITELNEVFK DLGSVVQQQG VLVDNIEANI 240
  241 YTTSDNTQLA SDELRKAMRY QKRTSRWRVY LLIVLLVMLL FIFLIMKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) PEP12 SEC20 SED5 SSO1 SSO2 TLG1 TLG2 UFE1
    View Details Gavin AC, et al. (2006) PEP12 SEC17 VTI1 YKT6
    View Details Qiu et al. (2008) BET1 PEP12 SED5 SNC1 SNC2 SSO1 SSO2 TLG1 TLG2 VAM3 VTI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE50 PEP12 2 Unpublished Fields Lab Data
    View Screen YPT31 PEP12 2 Uetz P, et al. (2000)
    View Screen YPT1 PEP12 2 Uetz P, et al. (2000)
    View Screen SST2 PEP12 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143]
    [203..288]    		 PSI-BLAST 86.0103 Syntaxin 1A N-terminal domain
    2 View Details [144..202] PSI-BLAST 86.0103 Syntaxin 1A N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNAP receptor activity
    		•  2.83778981988519 bayes_pls_golite062009
  • binding
    		•  2.18404492932496 bayes_pls_golite062009
  • protein binding
    		•  1.82422117934251 bayes_pls_golite062009
  • phosphatidic acid binding
    		•  1.52855006293534 bayes_pls_golite062009
  • transporter activity
    		•  0.487715383686856 bayes_pls_golite062009
  • SNARE binding
    		•  0.44377480710212 bayes_pls_golite062009
  • protein transporter activity
    		•  0.268987748407298 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0443963926233321 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle