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View Structure Prediction Details

Protein: PEP12
Organism: Saccharomyces cerevisiae
Length: 288 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEP12.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-52 [1..287] [11..294]
STX1A_MOUSE - Syntaxin-1A OS=Mus musculus GN=Stx1a PE=1 SV=3
 2.0E-51 [1..287] [1..284]
STX1A_RAT - Syntaxin-1A OS=Rattus norvegicus GN=Stx1a PE=1 SV=1
 8.0E-51 [1..287] [1..284]
gi|7595847, gi|7... - gi|7595847|gb|AAF64478.1| syntaxin 1A [Macaca mulatta], gi|74136291|ref|NP_001028037.1| syntaxin 1B ...
 1.0E-50 [1..287] [1..284]
gi|254071333, gi... - gi|254071333|gb|ACT64426.1| syntaxin 1A (brain) protein [synthetic construct], gi|254071331|gb|ACT64...
STX1A - syntaxin 1A (brain)
ENSCJAT00000032653 - null
 2.0E-50 [1..287] [1..284]
STX1A_BOVIN - Syntaxin-1A OS=Bos taurus GN=STX1A PE=1 SV=1
 4.0E-50 [1..287] [1..284]

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Predicted Domain #1
Region A:
Residues: [1-143] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEDEFFGGD NEAVWNGSRF SDSPEFQTLK EEVAAELFEI NGQISTLQQF TATLKSFIDR  60
   61 GDVSAKVVER INKRSVAKIE EIGGLIKKVN TSVKKMDAIE EASLDKTQII AREKLVRDVS 120
  121 YSFQEFQGIQ RQFTQVMKQV NER

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [203-288] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEISNIERGI TELNEVFKDL GSVVQQQGVL VDNIEANIYT TSDNTQLASD ELRKAMRYQK  60
   61 RTSRWRVYLL IVLLVMLLFI FLIMKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.0103
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNAP receptor activity 2.83778981988519 bayes_pls_golite062009
binding 2.18404492932496 bayes_pls_golite062009
protein binding 1.82422117934251 bayes_pls_golite062009
phosphatidic acid binding 1.52855006293534 bayes_pls_golite062009
transporter activity 0.487715383686856 bayes_pls_golite062009
SNARE binding 0.44377480710212 bayes_pls_golite062009
protein transporter activity 0.268987748407298 bayes_pls_golite062009
substrate-specific transporter activity 0.0443963926233321 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [144-202] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKESLEASEM ANDAALLDEE QRQNSSKSTR IPGSQIVIER DPINNEEFAY QQNLIEQRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.0103
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle