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Protein Overview: YKT6

General Information:
Name(s) found: YKT6 / YKL196C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 200 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    membrane [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    intra-Golgi vesicle-mediated transport [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [TASLink to PubMed article]
    palmitoyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIYYIGVFR SGGEKALELS EVKDLSQFGF FERSSVGQFM TFFAETVASR TGAGQRQSIE  60
   61 EGNYIGHVYA RSEGICGVLI TDKEYPVRPA YTLLNKILDE YLVAHPKEEW ADVTETNDAL 120
  121 KMKQLDTYIS KYQDPSQADA IMKVQQELDE TKIVLHKTIE NVLQRGEKLD NLVDKSESLT 180
  181 ASSKMFYKQA KKSNSCCIIM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSL1 SEC17 SEC39 TIP20 VTI1 YKT6
    View Details (MIPS) Mewes HW, et al. (2004) NYV1 YKT6
    View Details Gavin AC, et al. (2006) PEP12 SEC17 VTI1 YKT6
    View Details Gavin AC, et al. (2002) SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
    View Details Qiu et al. (2008) NYV1 SEC22 VAM7 YKT6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 sample: hx1 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 798.68867 Synaptobrevin homolog 1 ykt6
    2 View Details [138..200] PSI-BLAST 48.9897 Endobrevin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein-cysteine S-acyltransferase activity
    		•  5.70902768432932 bayes_pls_golite062009
  • protein-cysteine S-palmitoleyltransferase activity
    		•  5.70902768432932 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  2.42277624456482 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  2.39665981402803 bayes_pls_golite062009
  • SNAP receptor activity
    		•  2.23518960752054 bayes_pls_golite062009
  • clathrin binding
    		•  2.03985651011974 bayes_pls_golite062009
  • binding
    		•  1.76450203501026 bayes_pls_golite062009
  • transporter activity
    		•  1.71943098913274 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.939682472116899 bayes_pls_golite062009
  • hydrolase activity
    		•  0.815544630085919 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.66489873553532 bayes_pls_golite062009
  • protein binding
    		•  0.590936503990514 bayes_pls_golite062009
  • protein transporter activity
    		•  0.17469233791907 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.131410992694836 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0936690070284361 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0846345824909659 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0820309452260982 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle