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Protein Overview: TIP20

General Information:
Name(s) found: TIP20 / YGL145W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 701 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: retrograde vesicle-mediated transport, Golgi to ER [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIDDLLNI NDRIKQVQNE RNELASKLQN LKQSLASNDT EVALSEVIAQ DIIEVGASVE  60
   61 GLEQLRAKYG DLQILNKLEK VAVQQTQMQA GVDKLDSFER QLDELAEQPP DQFTLDDVKA 120
  121 LHSKLTSVFA TVPQINNIDS QYAAYNKLKS KVTGKYNDVI IQRLATNWSN TFDQKLLEAQ 180
  181 WDTQKFASTS VGLVKCLREN STKLYQLSLL YLPLEEETQN GDSERPLSRS NNNQEPVLWN 240
  241 FKSLANNFNV RFTYHFHATS SSSKIETYFQ FLNDYLAENL YKCINIFHDD CNGLTKPVIH 300
  301 EQFINYVLQP IRDKVRSTLF QNDLKTLIVL ISQILATDKN LLNSFHYHGL GLVSLISDEV 360
  361 WEKWINYEVE MANRQFINIT KNPEDFPKSS QNFVKLINKI YDYLEPFYDL DFDLLVRYKL 420
  421 MTCSLIFMNL TSSYLDYILT VDSLNETRTK EQELYQTMAK LQHVNFVYRK IKSLSSNFIF 480
  481 IQLTDIVNST ESKKYNSLFQ NVENDYEKAM STDMQNSIVH RIQKLLKETL RNYFKISTWS 540
  541 TLEMSVDENI GPSSVPSAEL VNSINVLRRL INKLDSMDIP LAISLKVKNE LLNVIVNYFT 600
  601 ESILKLNKFN QNGLNQFLHD FKSLSSILSL PSHATNYKCM SLHELVKILK LKYDPNNQQF 660
  661 LNPEYIKTGN FTSLKEAYSI KYLKDTKIQD ALYRIIYGNI L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSL1 SEC39 TIP20 UFE1 USE1 YKT6
    View Details Gavin AC, et al. (2006) DSL1 SEC39 TIP20 UFE1 USE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TIP20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164]
    [190..246]    		 ORFEUS 7.53 CBP80, 80KDa nuclear cap-binding protein
    2 View Details [165..189]
    [247..339]    		 ORFEUS 7.53 CBP80, 80KDa nuclear cap-binding protein
    3 View Details [340..432] ORFEUS 7.53 CBP80, 80KDa nuclear cap-binding protein
    4 View Details [433..630] ORFEUS 7.53 CBP80, 80KDa nuclear cap-binding protein
    5 View Details [631..701] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.22504663904848 bayes_pls_golite062009
  • binding
    		•  2.04447608076272 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.88229294781644 bayes_pls_golite062009
  • actin binding
    		•  0.92731255372235 bayes_pls_golite062009
  • actin filament binding
    		•  0.847123006562293 bayes_pls_golite062009
  • SNARE binding
    		•  0.309596137075689 bayes_pls_golite062009
  • syntaxin binding
    		•  0.214277649172074 bayes_pls_golite062009
  • protein complex binding
    		•  0.0466251755500114 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle