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Protein Overview: DSL1

General Information:
Name(s) found: DSL1 / YNL258C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 754 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: retrograde vesicle-mediated transport, Golgi to ER [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESLFPNKGE IIRELLKDPL ILKNDSKRSN GSELELDSSD LLQREAILAN ELNILDNLKT  60
   61 FLNLIKEVKT NLNILELENC YYSLQSLRKK MRNNAAYLKQ SFNFQQSIST YVDTLHLELV 120
  121 STLYKILTNG FWKITENSIQ FTPTVEWGKD KVHIEYDTFM DFVAQQYFPK GSLDNQAWFI 180
  181 LDMTSADSQE QVRAKLNTIM KEYMNLSRIV SMIKNSIFIS GKEISYENEK NILVFSKSSS 240
  241 HGQHCVSTVL TSFEAVCDFM LDGLAFRDRK TLSYELGPLF NTEFTKFVKN NASIILESLD 300
  301 SPLKNLVSVI NNKLTRLVAK SEVTNWTHSG KEIQDLLMNK QLYYNLLLDK VLESHISEIR 360
  361 SIFEDPKKSW QNLEVVELTT SNTNTMSEKI GKNDSDVQNE KELHNAVSKD DDWNWEVEDD 420
  421 DADAWGDEID VNIDDEEEKT NQEKEKEPEE EENAWDEAWA IDENIDDASL ENGKEHLKAH 480
  481 DVGSLDKDHI EVTQLPKLFL AISQNFKSSF ADSHVDEQYF AYKYNLLQTS YMAMCTANFS 540
  541 HNWCQLYVDM RYLIERDEKL YRIKELTRNL LETKLNMKYR IVCQLIRHQL TEFRENERNP 600
  601 SWDATIEKLL PYILKEIVRP LQKIRGEEGS RYLLSFLNFL YNDCVTKEIL KWQIISEVNS 660
  661 ENLGELVSLL VNNTDIQLLA KEPSYKKMRE KFATMGKFLP LHLKEIMEMF YNGDFYLFAT 720
  721 DELIQWIELL FADTPLRRNA IDDIYEIRGT ALDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSL1 SEC22 SEC39 TIP20 UFE1 USE1 YKT6
    View Details Gavin AC, et al. (2006) DSL1 SEC39 TIP20 UFE1 USE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DSL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..754] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle