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Protein Overview: SEC22

General Information:
Name(s) found: SEC22 / YLR268W [SGD]
Description(s) found:
Found 29 descriptions.
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  • R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 214 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [TASLink to PubMed article]
    vesicle fusion [TASLink to PubMed article]
    intra-Golgi vesicle-mediated transport [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKSTLIYRE DGLPLCTSVD NENDPSLFEQ KQKVKIVVSR LTPQSATEAT LESGSFEIHY  60
   61 LKKSMVYYFV ICESGYPRNL AFSYLNDIAQ EFEHSFANEY PKPTVRPYQF VNFDNFLQMT 120
  121 KKSYSDKKVQ DNLDQLNQEL VGVKQIMSKN IEDLLYRGDS LDKMSDMSSS LKETSKRYRK 180
  181 SAQKINFDLL ISQYAPIVIV AFFFVFLFWW IFLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSL1 SEC22 SEC39 UFE1 USE1
    View Details (MIPS) Mewes HW, et al. (2004) BET1 BOS1 GOS1 NYV1 SEC22 SNC1 SNC2 VTI1
    View Details Qiu et al. (2008) BET1 BOS1 COG2 COG3 COG7 GLO3 GOS1 MNN11 NYV1 RUD3 SEC20 SEC21 SEC22 SED5 SFT1 SLY1 SNC1 SNC2 SSO2 TLG1 TLG2 VRG4 VTI1 YIP3 YKT6

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC22 and ANP1 Huh WK, et al. (2003)
    View Data SEC22 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] PSI-BLAST 216.0103 Sec22b
    2 View Details [126..214] PSI-BLAST 72.156545 Endobrevin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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