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Protein Overview: TLG1

General Information:
Name(s) found: TLG1 / YDR468C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: early endosome [TASLink to PubMed article]
    trans-Golgi network [TASLink to PubMed article]
    Golgi trans cisterna [TASLink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNSEDPFQQ VVKDTKEQLN RINNYITRHN TAGDDDQEEE IQDILKDVEE TIVDLDRSII  60
   61 VMKRDENEDV SGREAQVKNI KQQLDALKLR FDRRIQESTQ TTIPLEETVE NSTLNTSMAE 120
  121 NNDGGMSNPF QEQMLREQDV HLDGIHKTMQ NLHIQAQTMG DELENQGQLL DNMDEGMDGV 180
  181 VNKLARGRRQ LEWVYEKNKE KYDDCCIGLL IVVLIVLLVL AFIA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) PEP12 SEC20 SED5 SSO1 SSO2 TLG1 TLG2 UFE1
    View Details Gavin AC, et al. (2002) SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
    View Details Qiu et al. (2008) DRS2 PEP12 SEC22 SED5 SNC1 SNC2 SSO1 SSO2 TLG1 TLG2 VTI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ALG13 No Comments Hazbun TR, et al. (2003)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93]
    [140..224]    		 PSI-BLAST 29.0 Syntaxin 1A N-terminal domain
    2 View Details [94..139] PSI-BLAST 29.0 Syntaxin 1A N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle