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Protein Overview: SED5

General Information:
Name(s) found: SED5 / YLR026C [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 340 amino acids

    Gene Ontology:
    Cellular Component: cis-Golgi network [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [TASLink to PubMed article]
    vesicle fusion [TASLink to PubMed article]
    intra-Golgi vesicle-mediated transport [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIKDRTSEF QQSVLSYKKR NKNFREQQRE RLQEKESENF ANNTTGNGKS VSEFQKKASG  60
   61 IAHEISSTAQ LLSKLAVLAK RKPMFNDNPV EIAELSFLIK RKIYAIEQSL VQLSQLKKTD 120
  121 VNGNTSNQSS KQPSAVQHSK NVVNLLNTQM KNISGSFKDV LEERQRLEMA NKDRWQKLTT 180
  181 DTGHAPADDQ TQSNHAADLT TYNNSNPFMT SLLDESSEKN NNSSNQGELS FPQNDSQLML 240
  241 MEEGQLSNNV YLQERNRAVE TIESTIQEVG NLFQQLASMV QEQGEVIQRI DANVDDIDLN 300
  301 ISGAQRELLK YFDRIKSNRW LAAKVFFIIF VFFVIWVLVN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) PEP12 SEC20 SED5 SSO1 SSO2 TLG1 TLG2 UFE1
    View Details Krogan NJ, et al. (2006) SED5 SLY1
    View Details Qiu et al. (2008) BET1 BET3 BET5 BOS1 COG3 COG7 GLO3 KRE11 PEP12 SEC20 SEC22 SED5 SFT1 SNC1 SNC2 SSO1 SSO2 TLG1 TLG2 TRS120 TRS23 TRS31 TRS33 VAM3 VTI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..45] ORFEUS 11.05 Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p
    2 View Details [46..203]
    [257..340]    		 PSI-BLAST 39.0 Syntaxin 1A N-terminal domain
    3 View Details [204..256] PSI-BLAST 39.0 Syntaxin 1A N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphatidic acid binding
    		•  6.29287857316152 bayes_pls_golite062009
  • SNAP receptor activity
    		•  3.50393203740159 bayes_pls_golite062009
  • binding
    		•  2.61337814857056 bayes_pls_golite062009
  • protein transporter activity
    		•  2.305772311362 bayes_pls_golite062009
  • protein binding
    		•  1.82422117934251 bayes_pls_golite062009
  • myosin head/neck binding
    		•  1.76421579737303 bayes_pls_golite062009
  • transporter activity
    		•  1.74189664015129 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.49085442233849 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13101548288086 bayes_pls_golite062009
  • arachidonic acid binding
    		•  1.11271369839161 bayes_pls_golite062009
  • SNARE binding
    		•  0.71459772253941 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.643064875848901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.370484918396857 bayes_pls_golite062009
  • channel activity
    		•  0.0647076360772156 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0647076360772156 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.0435980899803177 bayes_pls_golite062009
  • calcium channel inhibitor activity
    		•  0.0422996980911705 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.00476738027966683 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle