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View Structure Prediction Details

Protein: SED5
Organism: Saccharomyces cerevisiae
Length: 340 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SED5.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-49 [89..337] [1..251]
STX1A_MOUSE - Syntaxin-1A OS=Mus musculus GN=Stx1a PE=1 SV=3
 5.0E-47 [67..337] [9..280]
STX1A_BOVIN - Syntaxin-1A OS=Bos taurus GN=STX1A PE=1 SV=1
 8.0E-47 [67..337] [9..280]
STX1B_MOUSE - Syntaxin-1B OS=Mus musculus GN=Stx1b PE=1 SV=1
gi|251471 - gi|251471|gb|AAB22526.1| syntaxin, P35B [rats, brain, Peptide, 288 aa]
ENSCJAT00000005845 - null
gi|114662156 - gi|114662156|ref|XP_001145497.1| PREDICTED: similar to syntaxin B [Pan troglodytes]
STX1B - syntaxin 1B
STX1B_RAT - Syntaxin-1B OS=Rattus norvegicus GN=Stx1b PE=1 SV=1
 9.0E-47 [62..337] [2..279]
gi|254071333, gi... - gi|254071333|gb|ACT64426.1| syntaxin 1A (brain) protein [synthetic construct], gi|254071331|gb|ACT64...
STX1A - syntaxin 1A (brain)
ENSCJAT00000032653 - null
 9.0E-47 [71..337] [12..280]
gi|7595847, gi|7... - gi|7595847|gb|AAF64478.1| syntaxin 1A [Macaca mulatta], gi|74136291|ref|NP_001028037.1| syntaxin 1B ...
 1.0E-46 [67..337] [9..280]

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Predicted Domain #1
Region A:
Residues: [1-45] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIKDRTSEF QQSVLSYKKR NKNFREQQRE RLQEKESENF ANNTT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.05
Match: 1mqsB
Description: Crystal structure of Sly1p in complex with an N-terminal peptide of Sed5p
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [46-203] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNGKSVSEFQ KKASGIAHEI SSTAQLLSKL AVLAKRKPMF NDNPVEIAEL SFLIKRKIYA  60
   61 IEQSLVQLSQ LKKTDVNGNT SNQSSKQPSA VQHSKNVVNL LNTQMKNISG SFKDVLEERQ 120
  121 RLEMANKDRW QKLTTDTGHA PADDQTQSNH AADLTTYN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [257-340] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAVETIESTI QEVGNLFQQL ASMVQEQGEV IQRIDANVDD IDLNISGAQR ELLKYFDRIK  60
   61 SNRWLAAKVF FIIFVFFVIW VLVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphatidic acid binding 6.29287857316152 bayes_pls_golite062009
SNAP receptor activity 3.50393203740159 bayes_pls_golite062009
binding 2.61337814857056 bayes_pls_golite062009
protein transporter activity 2.305772311362 bayes_pls_golite062009
protein binding 1.82422117934251 bayes_pls_golite062009
myosin head/neck binding 1.76421579737303 bayes_pls_golite062009
transporter activity 1.74189664015129 bayes_pls_golite062009
substrate-specific transporter activity 1.49085442233849 bayes_pls_golite062009
transmembrane transporter activity 1.13101548288086 bayes_pls_golite062009
arachidonic acid binding 1.11271369839161 bayes_pls_golite062009
SNARE binding 0.71459772253941 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.643064875848901 bayes_pls_golite062009
ion transmembrane transporter activity 0.370484918396857 bayes_pls_golite062009
channel activity 0.0647076360772156 bayes_pls_golite062009
passive transmembrane transporter activity 0.0647076360772156 bayes_pls_golite062009
substrate-specific channel activity 0.0435980899803177 bayes_pls_golite062009
calcium channel inhibitor activity 0.0422996980911705 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009
cytoskeletal protein binding 0.00476738027966683 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [204-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSNPFMTSLL DESSEKNNNS SNQGELSFPQ NDSQLMLMEE GQLSNNVYLQ ERN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle