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Protein Overview: VAM3

General Information:
Name(s) found: VAM3 / YOR106W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; multispecificity vacuolar t-SNARE that mediates docking/fusion of multiple distinct late transport intermediates with the vacuole [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 283 amino acids

    Gene Ontology:
    Cellular Component: vacuolar membrane [IDALink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    Golgi to vacuole transport [TASLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFDIEAQS SKGNSQQEPQ FSTNQKTKEL SNLIETFAEQ SRVLEKECTK IGSKRDSKEL  60
   61 RYKIETELIP NCTSVRDKIE SNILIHQNGK LSADFKNLKT KYQSLQQSYN QRKSLFPLKT 120
  121 PISPGTSKER KDIHPRTEAV RQDPESSYIS IKVNEQSPLL HNEGQHQLQL QEEQEQQQQG 180
  181 LSQEELDFQT IIHQERSQQI GRIHTAVQEV NAIFHQLGSL VKEQGEQVTT IDENISHLHD 240
  241 NMQNANKQLT RADQHQRDRN KCGKVTLIII IVVCMVVLLA VLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) VAM3 VAM7
    View Details Qiu et al. (2008) PEP12 SED5 SSO1 VAM3 VMA9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 sample: hx1 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx2 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen VAM7 VAM3 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] PSI-BLAST 395.30103 Vam3p N-terminal domain
    2 View Details [122..185] deduced N/A No confident structure predictions are available.
    3 View Details [186..283] ORFEUS 13.98 Syntaxin 7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphatidic acid binding
    		•  4.54790612451186 bayes_pls_golite062009
  • SNAP receptor activity
    		•  3.50393203740159 bayes_pls_golite062009
  • binding
    		•  2.18404492932496 bayes_pls_golite062009
  • protein binding
    		•  1.82422117934251 bayes_pls_golite062009
  • transporter activity
    		•  1.74189664015129 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.2360389745429 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13101548288086 bayes_pls_golite062009
  • protein transporter activity
    		•  0.81087535212264 bayes_pls_golite062009
  • SNARE binding
    		•  0.71459772253941 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.398018181744571 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0981818568206971 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.00476738027966683 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphatidic acid binding
    		•  3.99289411123023 bayes_pls_golite062009
  • SNAP receptor activity
    		•  2.87584659156593 bayes_pls_golite062009
  • binding
    		•  2.10865031355861 bayes_pls_golite062009
  • protein binding
    		•  1.71065434412329 bayes_pls_golite062009
  • transporter activity
    		•  1.70608335538771 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.17569067269837 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13402377922348 bayes_pls_golite062009
  • protein transporter activity
    		•  0.593122950767464 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.396657939634767 bayes_pls_golite062009
  • SNARE binding
    		•  0.387098576112631 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0934422877951697 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle