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Protein Overview: DRS2

General Information:
Name(s) found: DRS2 / YAL026C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1355 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: phospholipid translocation [IMPLink to PubMed articleLink to PubMed article]
    post-Golgi vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    intracellular protein transport [IGILink to PubMed article]
    endocytosis [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [ISSLink to PubMed articleLink to PubMed article]
    phospholipid-translocating ATPase activity [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDDRETPPK RKPGEDDTLF DIDFLDDTTS HSGSRSKVTN SHANGYYIPP SHVLPEETID  60
   61 LDADDDNIEN DVHENLFMSN NHDDQTSWNA NRFDSDAYQP QSLRAVKPPG LFARFGNGLK 120
  121 NAFTFKRKKG PESFEMNHYN AVTNNELDDN YLDSRNKFNI KILFNRYILR KNVGDAEGNG 180
  181 EPRVIHINDS LANSSFGYSD NHISTTKYNF ATFLPKFLFQ EFSKYANLFF LCTSAIQQVP 240
  241 HVSPTNRYTT IGTLLVVLIV SAMKECIEDI KRANSDKELN NSTAEIFSEA HDDFVEKRWI 300
  301 DIRVGDIIRV KSEEPIPADT IILSSSEPEG LCYIETANLD GETNLKIKQS RVETAKFIDV 360
  361 KTLKNMNGKV VSEQPNSSLY TYEGTMTLND RQIPLSPDQM ILRGATLRNT AWIFGLVIFT 420
  421 GHETKLLRNA TATPIKRTAV EKIINRQIIR LFTVLIVLIL ISSIGNVIMS TADAKHLSYL 480
  481 YLEGTNKAGL FFKDFLTFWI LFSNLVPISL FVTVELIKYY QAFMIGSDLD LYYEKTDTPT 540
  541 VVRTSSLVEE LGQIEYIFSD KTGTLTRNIM EFKSCSIAGH CYIDKIPEDK TATVEDGIEV 600
  601 GYRKFDDLKK KLNDPSDEDS PIINDFLTLL ATCHTVIPEF QSDGSIKYQA ASPDEGALVQ 660
  661 GGADLGYKFI IRKGNSVTVL LEETGEEKEY QLLNICEFNS TRKRMSAIFR FPDGSIKLFC 720
  721 KGADTVILER LDDEANQYVE ATMRHLEDYA SEGLRTLCLA MRDISEGEYE EWNSIYNEAA 780
  781 TTLDNRAEKL DEAANLIEKN LILIGATAIE DKLQDGVPET IHTLQEAGIK IWVLTGDRQE 840
  841 TAINIGMSCR LLSEDMNLLI INEETRDDTE RNLLEKINAL NEHQLSTHDM KSLALVIDGK 900
  901 SLGFALEPEL EDYLLTVAKL CKAVICCRVS PLQKALVVKM VKRKSSSLLL AIASGANDVS 960
  961 MIQAAHVGVG ISGMEGMQAA RSADIALGQF KFLKKLLLVH GSWSYQRISV AILYSFYKNT1020
 1021 ALYMTQFWYV FANAFSGQSI MESWTMSFYN LFFTVWPPFV IGVFDQFVSS RLLERYPQLY1080
 1081 KLGQKGQFFS VYIFWGWIIN GFFHSAIVFI GTILIYRYGF ALNMHGELAD HWSWGVTVYT1140
 1141 TSVIIVLGKA ALVTNQWTKF TLIAIPGSLL FWLIFFPIYA SIFPHANISR EYYGVVKHTY1200
 1201 GSGVFWLTLI VLPIFALVRD FLWKYYKRMY EPETYHVIQE MQKYNISDSR PHVQQFQNAI1260
 1261 RKVRQVQRMK KQRGFAFSQA EEGGQEKIVR MYDTTQKRGK YGELQDASAN PFNDNNGLGS1320
 1321 NDFESAEPFI ENPFADGNQN SNRFSSSRDD ISFDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DRS2 MOT2 UBC4 UBC5 UFD4
    View Details Gavin AC, et al. (2006) DRS2 PDR5
    View Details Gavin AC, et al. (2002) DRS2 FKS1 FLC2 PDR5 TCB3
    View Details Qiu et al. (2008) ARF1 ARL1 CDC50 DNF3 DRS2 NEO1 SEC14 SNC1 SYS1 TLG1 TLG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DRS2 and COP1 Huh WK, et al. (2003)
    View Data DRS2 Huh WK, et al. (2003)
    View Data DRS2 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] deduced N/A No confident structure predictions are available.
    2 View Details [137..205]
    [285..434]    		 PSI-BLAST 1060.457575 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    3 View Details [206..274]
    [435..517]
    [1004..1265]    		 PSI-BLAST 1060.457575 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    4 View Details [275..284]
    [518..567]
    [813..1003]    		 PSI-BLAST 1060.457575 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    5 View Details [568..812] PSI-BLAST 1060.457575 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    6 View Details [1266..1355] MSA 4.081996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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