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Protein Overview: PDR5

General Information:
Name(s) found: PDR5 / YOR153W [SGD]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1511 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: drug transport [TASLink to PubMed article]
    response to drug [TASLink to PubMed article]
    Molecular Function: xenobiotic-transporting ATPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEAKLNNNV NDVTSYSSAS SSTENAADLH NYNGFDEHTE ARIQKLARTL TAQSMQNSTQ  60
   61 SAPNKSDAQS IFSSGVEGVN PIFSDPEAPG YDPKLDPNSE NFSSAAWVKN MAHLSAADPD 120
  121 FYKPYSLGCA WKNLSASGAS ADVAYQSTVV NIPYKILKSG LRKFQRSKET NTFQILKPMD 180
  181 GCLNPGELLV VLGRPGSGCT TLLKSISSNT HGFDLGADTK ISYSGYSGDD IKKHFRGEVV 240
  241 YNAEADVHLP HLTVFETLVT VARLKTPQNR IKGVDRESYA NHLAEVAMAT YGLSHTRNTK 300
  301 VGNDIVRGVS GGERKRVSIA EVSICGSKFQ CWDNATRGLD SATALEFIRA LKTQADISNT 360
  361 SATVAIYQCS QDAYDLFNKV CVLDDGYQIY YGPADKAKKY FEDMGYVCPS RQTTADFLTS 420
  421 VTSPSERTLN KDMLKKGIHI PQTPKEMNDY WVKSPNYKEL MKEVDQRLLN DDEASREAIK 480
  481 EAHIAKQSKR ARPSSPYTVS YMMQVKYLLI RNMWRLRNNI GFTLFMILGN CSMALILGSM 540
  541 FFKIMKKGDT STFYFRGSAM FFAILFNAFS SLLEIFSLYE ARPITEKHRT YSLYHPSADA 600
  601 FASVLSEIPS KLIIAVCFNI IFYFLVDFRR NGGVFFFYLL INIVAVFSMS HLFRCVGSLT 660
  661 KTLSEAMVPA SMLLLALSMY TGFAIPKKKI LRWSKWIWYI NPLAYLFESL LINEFHGIKF 720
  721 PCAEYVPRGP AYANISSTES VCTVVGAVPG QDYVLGDDFI RGTYQYYHKD KWRGFGIGMA 780
  781 YVVFFFFVYL FLCEYNEGAK QKGEILVFPR SIVKRMKKRG VLTEKNANDP ENVGERSDLS 840
  841 SDRKMLQESS EEESDTYGEI GLSKSEAIFH WRNLCYEVQI KAETRRILNN VDGWVKPGTL 900
  901 TALMGASGAG KTTLLDCLAE RVTMGVITGD ILVNGIPRDK SFPRSIGYCQ QQDLHLKTAT 960
  961 VRESLRFSAY LRQPAEVSIE EKNRYVEEVI KILEMEKYAD AVVGVAGEGL NVEQRKRLTI1020
 1021 GVELTAKPKL LVFLDEPTSG LDSQTAWSIC QLMKKLANHG QAILCTIHQP SAILMQEFDR1080
 1081 LLFMQRGGKT VYFGDLGEGC KTMIDYFESH GAHKCPADAN PAEWMLEVVG AAPGSHANQD1140
 1141 YYEVWRNSEE YRAVQSELDW MERELPKKGS ITAAEDKHEF SQSIIYQTKL VSIRLFQQYW1200
 1201 RSPDYLWSKF ILTIFNQLFI GFTFFKAGTS LQGLQNQMLA VFMFTVIFNP ILQQYLPSFV1260
 1261 QQRDLYEARE RPSRTFSWIS FIFAQIFVEV PWNILAGTIA YFIYYYPIGF YSNASAAGQL1320
 1321 HERGALFWLF SCAFYVYVGS MGLLVISFNQ VAESAANLAS LLFTMSLSFC GVMTTPSAMP1380
 1381 RFWIFMYRVS PLTYFIQALL AVGVANVDVK CADYELLEFT PPSGMTCGQY MEPYLQLAKT1440
 1441 GYLTDENATD TCSFCQISTT NDYLANVNSF YSERWRNYGI FICYIAFNYI AGVFFYWLAR1500
 1501 VPKKNGKLSK K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FLC2 PDR5
    View Details Krogan NJ, et al. (2006) GPD1 PDR5 PHO86 PMA1 PMT1 SSH1 WBP1 YGR266W
    View Details Gavin AC, et al. (2006) ADE5,7 BUD2 DRS2 PDR5 PET9 USA1
    View Details Gavin AC, et al. (2002) DRS2 FKS1 FLC2 PDR5 TCB3
    View Details Qiu et al. (2008) PDR5 QDR2 SNQ2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDR5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] deduced N/A No confident structure predictions are available.
    2 View Details [98..428] PSI-BLAST 147.679424 MJ0796
    3 View Details [429..493] deduced N/A No confident structure predictions are available.
    4 View Details [494..603]
    [623..848]    		 PSI-BLAST 141.917458 MsbA
    5 View Details [604..622]
    [849..1119]    		 PSI-BLAST 141.917458 MsbA
    6 View Details [1120..1420] MSA 3.525972 View MSA. No confident structure predictions are available.
    7 View Details [1421..1511] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • lipid transporter activity
    		•  7.47642599298853 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • sterol transporter activity
    		•  4.45355165759136 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrolase activity
    		•  3.67426835966263 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  2.72457626066894 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.26176677225712 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • eye pigment precursor transporter activity
    		•  2.19742277986318 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • binding
    		•  1.84115074893083 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • fluconazole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • azole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62884148289979 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • DNA binding
    		•  1.53176391519962 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.49517431175162 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.46975774710831 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  1.41230790551643 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • glycoprotein transporter activity
    		•  1.30536878174919 bayes_pls_golite062009
  • sterol-transporting ATPase activity
    		•  1.30536878174919 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.62832939629645 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.53788302029845 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • transcription factor activity
    		•  0.344643343870781 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  0.301752323171649 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.050232896280066 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0291047953833683 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.0122470146764899 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle