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Protein Overview: SSH1

General Information:
Name(s) found: SSH1 / YBR283C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    Sec61 translocon complex [TASLink to PubMed article]
    Biological Process: cotranslational protein targeting to membrane [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGFRLIDIV KPILPILPEV ELPFEKLPFD DKIVYTIFAG LIYLFAQFPL VGLPKATTPN  60
   61 VNDPIYFLRG VFGCEPRTLL EFGLFPNISS GLILQLLAGL KVIKVNFKIQ SDRELFQSLT 120
  121 KVFAIVQYVI LTNIFIFAGY FGDDLSVVQI GLINFQLVGA GIFTTLLAEV IDKGFGFSSG 180
  181 AMIINTVVIA TNLVADTFGV SQIKVGEDDQ TEAQGALINL IQGLRSKHKT FIGGIISAFN 240
  241 RDYLPNLTTT IIVLAIAIIV CYLQSVRVEL PIRSTRARGT NNVYPIKLLY TGCLSVLFSY 300
  301 TILFYIHIFA FVLIQLVAKN EPTHIICKIM GHYENANNLL AVPTFPLSLL APPTSFFKGV 360
  361 TQQPLTFITY SAFILVTGIW FADKWQAISG SSARDVALEF KDQGITLMGR REQNVAKELN 420
  421 KVIPIAAVTG ASVLSLITVI GESLGLKGKA AGIVVGIAGG FSLLEVITIE YQQSGGQSAL 480
  481 NQVLGVPGAM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GPD1 PDR5 PHO86 PMA1 PMT1 SSH1 WBP1 YGR266W
    View Details Qiu et al. (2008) SBH1 SBH2 SEC61 SEC62 SEC63 SEC66 SEC72 SRP102 SSH1 SSS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SSH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] MSA 1.113987 View MSA. No confident structure predictions are available.
    2 View Details [75..490] Pfam 6.142668 eubacterial secY protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonucleoprotein binding
    		•  5.96221631042313 bayes_pls_golite062009
  • protein transporter activity
    		•  5.55929343005534 bayes_pls_golite062009
  • transporter activity
    		•  3.32223562584466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.22714325269757 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.76187269823414 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • binding
    		•  1.4562802789412 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.01893828721893 bayes_pls_golite062009
  • protein binding
    		•  0.674651002700028 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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