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Protein Overview: SEC63

General Information:
Name(s) found: SEC63 / YOR254C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 663 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed articleLink to PubMed article]
    Sec62/Sec63 complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane [IMPLink to PubMed article]
    cytosol to ER transport [IMPLink to PubMed article]
    posttranslational protein targeting to membrane [IMPLink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTNYEYDEA SETWPSFILT GLLMVVGPMT LLQIYQIFFG ANAEDGNSGK SKEFNEEVFK  60
   61 NLNEEYTSDE IKQFRRKFDK NSNKKSKIWS RRNIIIIVGW ILVAILLQRI NSNDAIKDAA 120
  121 TKLFDPYEIL GISTSASDRD IKSAYRKLSV KFHPDKLAKG LTPDEKSVME ETYVQITKAY 180
  181 ESLTDELVRQ NYLKYGHPDG PQSTSHGIAL PRFLVDGSAS PLLVVCYVAL LGLILPYFVS 240
  241 RWWARTQSYT KKGIHNVTAS NFVSNLVNYK PSEIVTTDLI LHWLSFAHEF KQFFPDLQPT 300
  301 DFEKLLQDHI NRRDSGKLNN AKFRIVAKCH SLLHGLLDIA CGFRNLDIAL GAINTFKCIV 360
  361 QAVPLTPNCQ ILQLPNVDKE HFITKTGDIH TLGKLFTLED AKIGEVLGIK DQAKLNETLR 420
  421 VASHIPNLKI IKADFLVPGE NQVTPSSTPY ISLKVLVRSA KQPLIPTSLI PEENLTEPQD 480
  481 FESQRDPFAM MSKQPLVPYS FAPFFPTKRR GSWCCLVSSQ KDGKILQTPI IIEKLSYKNL 540
  541 NDDKDFFDKR IKMDLTKHEK FDINDWEIGT IKIPLGQPAP ETVGDFFFRV IVKSTDYFTT 600
  601 DLDITMNMKV RDSPAVEQVE VYSEEDDEYS TDDDETESDD ESDASDYTDI DTDTEAEDDE 660
  661 SPE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SEC62 SEC63 SEC66 SEC72
    View Details Hazbun TR, et al. (2003) AIM25 DED81 GWT1 MRC1 SEC63 SEC7
    View Details (MIPS) Mewes HW, et al. (2004) SEC62 SEC63 SEC66 SEC72
    View Details Krogan NJ, et al. (2006) SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2006) SEC62 SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2002) ANP1 FKS1 MNN10 SEC62 SEC63 SEC66 SEC72
    View Details Qiu et al. (2008) SBH1 SBH2 SEC61 SEC62 SEC63 SEC66 SEC72 SSH1 SSS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC63 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] deduced N/A No confident structure predictions are available.
    2 View Details [117..241] PSI-BLAST 127.502279 DnaJ chaperone, N-terminal (J) domain
    3 View Details [242..663] MSA 12.139943 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • signal recognition particle binding
    		•  3.28103883404258 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  2.20695097776982 bayes_pls_golite062009
  • protein binding
    		•  2.0077819170005 bayes_pls_golite062009
  • binding
    		•  1.75184008862922 bayes_pls_golite062009
  • transporter activity
    		•  1.29863098651348 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  1.13087926351787 bayes_pls_golite062009
  • protein transporter activity
    		•  0.939490372372376 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.91241047562027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.812144232432417 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.796066295738949 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transporter activity
    		•  2.46466249895824 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.40264381204753 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.37642404692102 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.37262306131842 bayes_pls_golite062009
  • potassium channel activity
    		•  2.35561670403632 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.33426249687556 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  2.33102664959792 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.32502571419352 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.32465304131102 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.3181005726144 bayes_pls_golite062009
  • channel activity
    		•  2.3181005726144 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.31677709260544 bayes_pls_golite062009
  • cation channel activity
    		•  2.30081429233977 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.28077016868353 bayes_pls_golite062009
  • ion channel activity
    		•  2.2553711462771 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.23522391314947 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.2162185402774 bayes_pls_golite062009
  • gated channel activity
    		•  2.16810998541959 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.15379228421204 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.00003070639929 bayes_pls_golite062009
  • ATPase activity
    		•  1.94063929259701 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.93031967085303 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.91231918357992 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.90999409453671 bayes_pls_golite062009
  • protein binding
    		•  1.90127097529706 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  1.86598930407084 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.81486809950722 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.81486809950722 bayes_pls_golite062009
  • binding
    		•  1.77589663168522 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.56566273004515 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.223800319644873 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.223800319644873 bayes_pls_golite062009
  • helicase activity
    		•  0.166899434976303 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.0561411188724552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.0447036496272264 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle