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Protein Overview: GWT1

General Information:
Name(s) found: GWT1 / YJL091C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [IDALink to PubMed article]
    Molecular Function: glucosaminyl-phosphotidylinositol O-acyltransferase activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLKQRKED FVTGLNGGSI TEINAVTSIA LVTYISWNLL KNSNLMPPGI SSVQYIIDFA  60
   61 LNWVALLLSI TIYASEPYLL NTLILLPCLL AFIYGKFTSS SKPSNPIYNK KKMITQRFQL 120
  121 EKKPYITAYR GGMLILTAIA ILAVDFPIFP RRFAKVETWG TSLMDLGVGS FVFSNGIVSS 180
  181 RALLKNLSLK SKPSFLKNAF NALKSGGTLL FLGLLRLFFV KNLEYQEHVT EYGVHWNFFI 240
  241 TLSLLPLVLT FIDPVTRMVP RCSIAIFISC IYEWLLLKDD RTLNFLILAD RNCFFSANRE 300
  301 GIFSFLGYCS IFLWGQNTGF YLLGNKPTLN NLYKPSTQDV VAASKKSSTW DYWTSVTPLS 360
  361 GLCIWSTIFL VISQLVFQYH PYSVSRRFAN LPYTLWVITY NLLFLTGYCL TDKIFGNSSE 420
  421 YYKVAECLES INSNGLFLFL LANVSTGLVN MSMVTIDSSP LKSFLVLLAY CSFIAVISVF 480
  481 LYRKRIFIKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) AIM25 DED81 GWT1 MRC1 SEC63 SEC7
    View Details Qiu et al. (2008) GPI11 GWT1 LAS21 LCB1 STT3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GWT1 and TRX3 Hazbun TR, et al. (2003)
    View Data GWT1 and TRX3 Hazbun TR, et al. (2003)
    View Data GWT1 and SPC42 Hazbun TR, et al. (2003)
    View Data GWT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] MSA 1.024971 View MSA. No confident structure predictions are available.
    2 View Details [191..266] deduced N/A No confident structure predictions are available.
    3 View Details [267..490] Pfam 77.045757 No description for PF06423.1 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle