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Protein Overview: LAS21

General Information:
Name(s) found: LAS21 / YJL062W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 830 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: mannose-ethanolamine phosphotransferase activity [IMPLink to PubMed article]
    transferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLKQFTCLS CAQLLAILLF IFAFFPRKIV LTGISKQDPD QDRDLQRDRP FQKLVFVIID  60
   61 ALRSDFLFDS QISHFNNVHQ WLNTGEAWGY TSFANPPTVT LPRLKSITTG STPSFIDLLL 120
  121 NVAQDIDSND LSEHDSWLQQ FIQHNNTIRF MGDDTWLKLF PQQWFDFADP THSFFVSDFT 180
  181 QVDNNVTRNL PGKLFQEWAQ WDVAILHYLG LDHIGHKDGP HSKFMAAKHQ EMDSILKSIY 240
  241 DEVLEHEDDD DTLICVLGDH GMNELGNHGG SSAGETSAGL LFLSPKLAQF ARPESQVNYT 300
  301 LPINASPDWN FQYLETVQQI DIVPTIAALF GMPIPMNSVG IIIPDFLQLL PNKLASMKEN 360
  361 FMHLWKLSDH HGEVALDDFT AEDIYTKMYT IQETLTKSAT NYNYPLLTLA FVGFLIITII 420
  421 AIYVLLRYSG PDFWQLRVSS LSVLLVSIIL GVSTFASSFI EEEHQLWWWI VTAFSAVPLF 480
  481 VYRLNVLIIV RWFIMMACVR SIKFWNNSGQ KFIYSNVMSN LLNQNPSWKW CLNMLTFLVL 540
  541 IMASAGFQVL HFIVTTILVG LCFTYKISWE IVNGNQAEIP LFMHDLLAKI DFAPTESNLI 600
  601 VLARVFFQAW AIVVISRLVL TKLKVLNKNY LIKDMKVYIT ILLMFQTSSQ NIGQFLVFQI 660
  661 LESQIFYFFQ NIPTASLTST SKIYFSNLVS LILQNFTFFQ FGGTNSISTI DLGNAYHGVS 720
  721 SDYNIYVVGI LMSVANFAPA IYWSMLPWSI NYASIPAQVK LQTFIRSKLP AFTYHCIFGT 780
  781 CLMTACVVLR FHLFIWSVFS PKLCYFLGWN FVMGLLNGWL PELALLCALD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GPI11 GPI13 GPI8 GWT1 LAS21

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LAS21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] PSI-BLAST 34.522879 Arylsulfatase A
    2 View Details [379..508] MSA 1.037997 View MSA. Confident ab initio structure predictions are available.
    3 View Details [509..704] deduced N/A No confident structure predictions are available.
    4 View Details [705..830] MSA 2.019984 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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