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Protein Overview: GPI13

General Information:
Name(s) found: GPI13 / YLL031C [SGD]
Description(s) found:
Found 24 descriptions.
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  • ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1017 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [ISSLink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: mannose-ethanolamine phosphotransferase activity [IMPLink to PubMed article]
    transferase activity, transferring phosphorus-containing groups [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEKTIKKSI LSSSNDEKII YKSRIKKFQK NHKFYIILLV FIAILQFISI AFFTRGFLLS  60
   61 RHVLDNISSQ NETSKLPPRF NKAVILVIDA LRFDFAIPVN ESHSNYNLNY HNNILSLYDS 120
  121 FASDKDASSL LLKFIADPPT TTLQRLKGLT TGSLPTFIDA GSNFDGTVIE EDNFLKQLHL 180
  181 ANKTVKFAGD DTWMALFHPF LSNDSFPLES LNVWDLDTVD NGVMDYFHDH LQQDKEWDVM 240
  241 IGHMLGIDHV GHKYGPDHFT MREKQIQVDQ FIDWILKSID DDTLLVILGD HGMDHTGNHG 300
  301 GDSIDELEST LFLYSKKPDM WRLKETSNYN IDNLGHDYRS VRQIDLVSSL ALLMGQPIPF 360
  361 NNLGWPIDEI ARNDREWSQF VNSAISQLQL YKDTMQIHHG NDEILEPLAK NISNTPPTSD 420
  421 PEKFVKLGHK YQKVFLQTCE ELWAKFDYYS IATGITLLAT SLVLLISITK LIPSIVVNQM 480
  481 VPEFVPGIII MVLVTNLCFH GIFYVYQQPS FVDQFWGTLL ATAIGIIIGC YITIFDRYNF 540
  541 IWIAMRLGET LADYWSRIAV MFMIIHALLF TSNSFTIWED RIVAFLLSTF GMLTLYEFVF 600
  601 LPKRQSTTAL LTATISEKEG TTSGVNPSTA NSNYLPLTRF ARLLGGYHSA VLIIFTRLAS 660
  661 MITICREEQG EYCIPTFNNQ NNSSWWVLGL CFLMIFILPA CITGYYNLTS SYQAAAPIWI 720
  721 NVFLKGILGL NFVYWSLTSL ENNSAVIAIP FLRDVTIFKF TLARIIAGFS LIASNVGWLM 780
  781 GPLCIKLNIH NTDVKSHEAT ILGYTNIYGS EFFLLVINVL ISILLFNKPL AQLSYFLMCN 840
  841 QLLSILEIID LLKLKENIIG PIALGLLSYQ HFFTTGHQAT IPSVQWDIGF MLSEKVTFPF 900
  901 TQIAIILNTF GPHILVSLSV ALLTLWSQPP DVLKPQTLLG RIVSNCGILL TYNTILCLSS 960
  961 FIWVTHFRRH LMVWKIFCPR FIFASLSLIV TQLVVTFGTI AFASGRLIKH INDIFWK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GPI11 GPI13 LAS21 MCD4 PIS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GPI13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..413] PSI-BLAST 37.30103 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain; 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain
    3 View Details [414..556] MSA 1.046996 View MSA. Confident ab initio structure predictions are available.
    4 View Details [557..620] deduced N/A No confident structure predictions are available.
    5 View Details [621..1017] MSA 3.010934 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle