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Protein Overview: PIS1

General Information:
Name(s) found: PIS1 / YPR113W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 220 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    microsome [IDALink to PubMed article]
    endoplasmic reticulum [TAS]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: phosphatidylinositol biosynthetic process [IMPLink to PubMed article][TAS]
    cell cycle [IMPLink to PubMed article]
    Molecular Function: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [IMPLink to PubMed article][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNSTPEKV TAEHVLWYIP NKIGYVRVIT AALSFFVMKN HPTAFTWLYS TSCLLDALDG  60
   61 TMARKYNQVS SLGAVLDMVT DRSSTAGLMC FLCVQYPQWC VFFQLMLGLD ITSHYMHMYA 120
  121 SLSAGKTSHK SVGEGESRLL HLYYTRRDVL FTICAFNELF YAGLYLQLFS NSATFGKWTT 180
  181 IISFPGYVFK QTANVVQLKR AALILADNDA KNANEKNKTY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CPT1 GPI11 GPI13 LCB1 LCB2 PIS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PIS1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] Pfam 31.920819 CDP-alcohol phosphatidyltransferase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.37

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle