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Protein Overview: MCD4

General Information:
Name(s) found: MCD4 / YKL165C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 919 amino acids

    Gene Ontology:
    Cellular Component: fungal-type cell wall [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    ATP transport [IDALink to PubMed article]
    Molecular Function: mannose-ethanolamine phosphotransferase activity [IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWNKTRTTLL AVGVLFHLFY LWSIFDIYFI SPLVHGMSPY QSTPTPPAKR LFLIVGDGLR  60
   61 ADTTFDKVTH PVSGKTEFLA PFIRSLVMNN ATYGISHTRM PTESRPGHVA MIAGFYEDVS 120
  121 AVTKGWKSNP VNFDSFFNQS THTYSFGSPD ILPMFKDGAS DPNKVDTWMY DHTFEDFTQS 180
  181 SIELDAFVFR HLDQLFHNST LNSTLDYEIR QDGNVFFLHL LGCDTAGHSY RPYSAEYYDN 240
  241 VKYIDDQIPI LIDKVNKFFA DDKTAFIFTA DHGMSAFGSH GDGHPNNTRT PLVAWGAGLN 300
  301 KPVHNPFPVS DNYTENWELS SIKRNDVKQA DIASLMSYLI GVNYPKNSVG ELPIAYIDGK 360
  361 ESDKLAALYN NARSILEQYL VKQDEVIDSQ FFYKEYFKFV EKSHSHYLEE IETLIQRISE 420
  421 GENYLEQEAI TLTEELMQIT LEGLHYLTTY NWRFIRTIVT FGFVGWIFFS FIIFLKSFIL 480
  481 ENVIDDQKAS PLSHAVFGSI GILLNWILFY QHSPFNFYMY LLFPLYFWSY IFTNRSVLRS 540
  541 GIKEFFKGTS PWKRVLITIS IISVYEGIVY GFFHRWTFTL ITNILAFYPF ICGVRELSVN 600
  601 ILWIITSVLL STFTLFDAVK IEDLNQIHLA GLLIILSAFY ALYKIHSRIN SYTRAIFAIQ 660
  661 ISLVAAMLAV THRSVISLQL RQGLPRESQV AGWIIFFVSL FVMPILHYRK PNNDYKVRLL 720
  721 IIYLTFAPSF IILTISFESL FYFLFTSYMV QWIEIENKIK EMKTQKDENW LQVLRVSVIG 780
  781 FFLLQVAFFG TGNVASISSF SLESVCRLLP IFDPFLMGAL LMLKLIIPYG LLSTCLGILN 840
  841 LKLNFKDYTI SSLIISMSDI LSLNFFYLLR TEGSWLDIGI TISNYCLAIL SSLFMLILEV 900
  901 LGHVLLKNVI IQDKTKKTQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CPT1 GPI11 GPI13 MCD4 PFA3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MCD4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..383] PSI-BLAST 33.221849 Arylsulfatase A
    2 View Details [384..535] MSA 1.072993 View MSA. Confident ab initio structure predictions are available.
    3 View Details [536..919] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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