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Protein Overview: PFA3

General Information:
Name(s) found: PFA3 / YNL326C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 336 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: protein amino acid palmitoylation [IDALink to PubMed article][ISSLink to PubMed article]
    vacuole fusion, non-autophagic [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein-cysteine S-palmitoleyltransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDRLSLTSL FPRCLTTCLY IWTAYITLTR IHQIPRWFLA LTIVPTLAVA LYTYYKVIAR  60
   61 GPGSPLDFPD LLVHDLKAAE NGLELPPEYM SKRCLTLKHD GRFRVCQVCH VWKPDRCHHC 120
  121 SSCDVCILKM DHHCPWFAEC TGFRNQKFFI QFLMYTTLYA FLVLIYTCYE LGTWFNSGSF 180
  181 NRELIDFHLL GVALLAVAVF ISVLAFTCFS IYQVCKNQTT IEVHGMRRYR RDLEILNDSY 240
  241 GTNEHLENIF DLGSSMANWQ DIMGTSWLEW ILPIETFKYK KSKHTKDEKG LYFNVRPQVQ 300
  301 DRLLSSRCLE DQLLRRVTPR PSLEADRASV EIIDAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MCD4 PFA3 SHR5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PFA3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] deduced N/A No confident structure predictions are available.
    2 View Details [83..178] Pfam 37.481486 DHHC zinc finger domain No confident structure predictions are available.
    3 View Details [179..336] MSA 1.130993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone acetyltransferase activity
    		•  2.27787208911046 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  2.27787208911046 bayes_pls_golite062009
  • binding
    		•  2.26426010117912 bayes_pls_golite062009
  • protein binding
    		•  1.53664633945707 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.14293461071656 bayes_pls_golite062009
  • DNA binding
    		•  1.01821892002729 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.868529388780493 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.812614536174423 bayes_pls_golite062009
  • phospholipid binding
    		•  0.681239636602955 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.565596821175093 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.514633973697725 bayes_pls_golite062009
  • histone binding
    		•  0.440372329067948 bayes_pls_golite062009
    		• 0.308979985902751 bayes_pls_golite062009
  • transcription factor activity
    		•  0.204306775436268 bayes_pls_golite062009
  • ligase activity
    		•  0.161281682592326 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle