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View Structure Prediction Details

Protein: PFA3
Organism: Saccharomyces cerevisiae
Length: 336 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFA3.

Description E-value Query
Range
Subject
Range
PFA3 - Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-c...
PFA3_YEAST - Palmitoyltransferase PFA3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFA3 PE=1 SV=1
1.0E-88 [1..336] [1..336]
ZDHC5_MOUSE - Palmitoyltransferase ZDHHC5 OS=Mus musculus GN=Zdhhc5 PE=1 SV=1
8.0E-52 [5..324] [17..301]
ZDHC2_RAT - Palmitoyltransferase ZDHHC2 OS=Rattus norvegicus GN=Zdhhc2 PE=2 SV=1
1.0E-51 [12..278] [21..286]
ZDHHC2 - zinc finger, DHHC-type containing 2
2.0E-51 [12..277] [22..286]
gi|220942256 - gi|220942256|gb|ACL83671.1| CG1407-PB [synthetic construct]
CG1407-PB - This gene is referred to in FlyBase by the symbol Dmel\CG1407 (CG1407, FBgn0033474). It is a protein...
1.0E-49 [12..277] [24..293]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDRLSLTSL FPRCLTTCLY IWTAYITLTR IHQIPRWFLA LTIVPTLAVA LYTYYKVIAR  60
   61 GPGSPLDFPD LLVHDLKAAE NG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 2.27787208911046 bayes_pls_golite062009
lysine N-acetyltransferase activity 2.27787208911046 bayes_pls_golite062009
binding 2.26426010117912 bayes_pls_golite062009
protein binding 1.53664633945707 bayes_pls_golite062009
transcription regulator activity 1.14293461071656 bayes_pls_golite062009
DNA binding 1.01821892002729 bayes_pls_golite062009
nucleic acid binding 0.868529388780493 bayes_pls_golite062009
phosphoinositide binding 0.812614536174423 bayes_pls_golite062009
phospholipid binding 0.681239636602955 bayes_pls_golite062009
N-acyltransferase activity 0.565596821175093 bayes_pls_golite062009
N-acetyltransferase activity 0.514633973697725 bayes_pls_golite062009
histone binding 0.440372329067948 bayes_pls_golite062009
0.308979985902751 bayes_pls_golite062009
transcription factor activity 0.204306775436268 bayes_pls_golite062009
ligase activity 0.161281682592326 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [83-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LELPPEYMSK RCLTLKHDGR FRVCQVCHVW KPDRCHHCSS CDVCILKMDH HCPWFAECTG  60
   61 FRNQKFFIQF LMYTTLYAFL VLIYTCYELG TWFNSG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 37.481486
Match: PF01529
Description: DHHC zinc finger domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [179-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFNRELIDFH LLGVALLAVA VFISVLAFTC FSIYQVCKNQ TTIEVHGMRR YRRDLEILND  60
   61 SYGTNEHLEN IFDLGSSMAN WQDIMGTSWL EWILPIETFK YKKSKHTKDE KGLYFNVRPQ 120
  121 VQDRLLSSRC LEDQLLRRVT PRPSLEADRA SVEIIDAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle