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View Structure Prediction Details

Protein: PFA3
Organism: Saccharomyces cerevisiae
Length: 336 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFA3.

Description E-value Query
Range
Subject
Range
PFA3 - Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-c...
PFA3_YEAST - Palmitoyltransferase PFA3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFA3 PE=1 SV=1
1.0E-88 [1..336] [1..336]
ZDHC5_MOUSE - Palmitoyltransferase ZDHHC5 OS=Mus musculus GN=Zdhhc5 PE=1 SV=1
8.0E-52 [5..324] [17..301]
ZDHC2_RAT - Palmitoyltransferase ZDHHC2 OS=Rattus norvegicus GN=Zdhhc2 PE=2 SV=1
1.0E-51 [12..278] [21..286]
ZDHHC2 - zinc finger, DHHC-type containing 2
2.0E-51 [12..277] [22..286]
gi|220942256 - gi|220942256|gb|ACL83671.1| CG1407-PB [synthetic construct]
CG1407-PB - This gene is referred to in FlyBase by the symbol Dmel\CG1407 (CG1407, FBgn0033474). It is a protein...
1.0E-49 [12..277] [24..293]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDRLSLTSL FPRCLTTCLY IWTAYITLTR IHQIPRWFLA LTIVPTLAVA LYTYYKVIAR  60
   61 GPGSPLDFPD LLVHDLKAAE NG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 2.27787208911046 bayes_pls_golite062009
lysine N-acetyltransferase activity 2.27787208911046 bayes_pls_golite062009
binding 2.26426010117912 bayes_pls_golite062009
protein binding 1.53664633945707 bayes_pls_golite062009
transcription regulator activity 1.14293461071656 bayes_pls_golite062009
DNA binding 1.01821892002729 bayes_pls_golite062009
nucleic acid binding 0.868529388780493 bayes_pls_golite062009
phosphoinositide binding 0.812614536174423 bayes_pls_golite062009
phospholipid binding 0.681239636602955 bayes_pls_golite062009
N-acyltransferase activity 0.565596821175093 bayes_pls_golite062009
N-acetyltransferase activity 0.514633973697725 bayes_pls_golite062009
histone binding 0.440372329067948 bayes_pls_golite062009
0.308979985902751 bayes_pls_golite062009
transcription factor activity 0.204306775436268 bayes_pls_golite062009
ligase activity 0.161281682592326 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [83-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LELPPEYMSK RCLTLKHDGR FRVCQVCHVW KPDRCHHCSS CDVCILKMDH HCPWFAECTG  60
   61 FRNQKFFIQF LMYTTLYAFL VLIYTCYELG TWFNSG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 37.481486
Match: PF01529
Description: DHHC zinc finger domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.586 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.558 N/A N/A a.25.1 Ferritin-like
View Download 0.554 N/A N/A a.25.1 Ferritin-like
View Download 0.515 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.482 N/A N/A a.118.8 TPR-like

Predicted Domain #3
Region A:
Residues: [179-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFNRELIDFH LLGVALLAVA VFISVLAFTC FSIYQVCKNQ TTIEVHGMRR YRRDLEILND  60
   61 SYGTNEHLEN IFDLGSSMAN WQDIMGTSWL EWILPIETFK YKKSKHTKDE KGLYFNVRPQ 120
  121 VQDRLLSSRC LEDQLLRRVT PRPSLEADRA SVEIIDAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.558 0.216 fungal-type vacuole a.25.1 Ferritin-like
View Download 0.482 0.074 fungal-type vacuole a.118.8 TPR-like
View Download 0.586 0.052 fungal-type vacuole a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.554 N/A N/A a.25.1 Ferritin-like
View Download 0.515 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.469 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.449 N/A N/A a.26.1 4-helical cytokines
View Download 0.441 N/A N/A a.149.1 RNase III endonuclease catalytic domain
View Download 0.416 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.415 N/A N/A a.118.8 TPR-like
View Download 0.405 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.385 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.383 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.382 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.378 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.378 N/A N/A a.47.2 t-snare proteins
View Download 0.366 N/A N/A a.3.1 Cytochrome c
View Download 0.366 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.359 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.355 N/A N/A a.26.1 4-helical cytokines
View Download 0.353 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.345 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.337 N/A N/A a.26.1 4-helical cytokines
View Download 0.336 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.322 N/A N/A d.123.1 Sporulation responce regulatory protein Spo0B
View Download 0.322 N/A N/A a.168.1 GEF domain of SopE toxin
View Download 0.319 N/A N/A a.25.1 Ferritin-like
View Download 0.316 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.312 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.312 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.301 N/A N/A a.47.2 t-snare proteins
View Download 0.297 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.290 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.278 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.274 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.271 N/A N/A f.1.5 Exotoxin A, middle domain
View Download 0.268 N/A N/A a.7.1 Spectrin repeat
View Download 0.264 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.245 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.245 N/A N/A a.7.1 Spectrin repeat
View Download 0.244 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.244 N/A N/A a.26.1 4-helical cytokines
View Download 0.235 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.231 N/A N/A a.18.1 T4 endonuclease V
View Download 0.229 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.221 N/A N/A a.118.1 ARM repeat
View Download 0.220 N/A N/A d.135.1 The spindle assembly checkpoint protein mad2
View Download 0.219 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.219 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.218 N/A N/A a.47.2 t-snare proteins
View Download 0.211 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.209 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.209 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.201 N/A N/A c.23.1 CheY-like
View Download 0.200 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle