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View Structure Prediction Details

Protein: LAS21
Organism: Saccharomyces cerevisiae
Length: 830 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAS21.

Description E-value Query
Range
Subject
Range
gi|14029404 - gi|14029404|gb|AAK52677.1|AF321466_1 putative protein Gpi7p [Yarrowia lipolytica]
537.0 [0..7] [829..10]
GPI7_YARLI - GPI ethanolamine phosphate transferase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LAS21 P...
GPI7_YARLI - GPI ethanolamine phosphate transferase 2 OS=Yarrowia lipolytica GN=LAS21 PE=3 SV=1
534.0 [0..7] [829..10]
gi|19070511 - gi|19070511|gb|AAL83897.1|AF348498_1 putative Gpi7p [Candida albicans]
520.0 [0..9] [822..15]
gi|20306653 - gi|20306653|gb|AAH28363.1| Phosphatidylinositol glycan anchor biosynthesis, class N [Homo sapiens]
481.0 [0..8] [789..3]
gi|114673382, gi... - gi|114673382|ref|XP_001144550.1| PREDICTED: phosphatidylinositol glycan anchor biosynthesis, class N...
477.0 [0..8] [789..3]
gpi7 - GPI anchor biosynthesis protein Gpi7
GPI7_SCHPO - GPI ethanolamine phosphate transferase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=l...
472.0 [0..1] [828..1]
CE35863 - Yeast YJ10 like status:Partially_confirmed UniProt:Q19870 protein_id:CAA92675.2
466.0 [0..6] [816..10]

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Predicted Domain #1
Region A:
Residues: [1-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLKQFTCLS CAQLLAILLF IFAFFPRKIV LTGISKQDPD QDRDLQRDRP FQKLVFVIID  60
   61 ALRSDFLFDS QISHFNNVHQ WLNTGEAWGY TSFANPPTVT LPRLKSITTG STPSFIDLLL 120
  121 NVAQDIDSND LSEHDSWLQQ FIQHNNTIRF MGDDTWLKLF PQQWFDFADP THSFFVSDFT 180
  181 QVDNNVTRNL PGKLFQEWAQ WDVAILHYLG LDHIGHKDGP HSKFMAAKHQ EMDSILKSIY 240
  241 DEVLEHEDDD DTLICVLGDH GMNELGNHGG SSAGETSAGL LFLSPKLAQF ARPESQVNYT 300
  301 LPINASPDWN FQYLETVQQI DIVPTIAALF GMPIPMNSVG IIIPDFLQLL PNKLASMKEN 360
  361 FMHLWKLSDH HGEVALDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.522879
Match: 1e3cP
Description: Arylsulfatase A
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [379-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTAEDIYTKM YTIQETLTKS ATNYNYPLLT LAFVGFLIIT IIAIYVLLRY SGPDFWQLRV  60
   61 SSLSVLLVSI ILGVSTFASS FIEEEHQLWW WIVTAFSAVP LFVYRLNVLI IVRWFIMMAC 120
  121 VRSIKFWNNS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.994 N/A N/A a.24.9 alpha-catenin/vinculin

Predicted Domain #3
Region A:
Residues: [509-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQKFIYSNVM SNLLNQNPSW KWCLNMLTFL VLIMASAGFQ VLHFIVTTIL VGLCFTYKIS  60
   61 WEIVNGNQAE IPLFMHDLLA KIDFAPTESN LIVLARVFFQ AWAIVVISRL VLTKLKVLNK 120
  121 NYLIKDMKVY ITILLMFQTS SQNIGQFLVF QILESQIFYF FQNIPTASLT STSKIYFSNL 180
  181 VSLILQNFTF FQFGGT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [705-830]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSISTIDLGN AYHGVSSDYN IYVVGILMSV ANFAPAIYWS MLPWSINYAS IPAQVKLQTF  60
   61 IRSKLPAFTY HCIFGTCLMT ACVVLRFHLF IWSVFSPKLC YFLGWNFVMG LLNGWLPELA 120
  121 LLCALD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.915 N/A N/A a.24.9 alpha-catenin/vinculin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle