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Protein Overview: STT3

General Information:
Name(s) found: STT3 / YGL022W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 718 amino acids

    Gene Ontology:
    Cellular Component: oligosaccharyltransferase complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: protein amino acid N-linked glycosylation [IPILink to PubMed article]
    Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSDRSCVLS VFQTILKLVI FVAIFGAAIS SRLFAVIKFE SIIHEFDPWF NYRATKYLVN  60
   61 NSFYKFLNWF DDRTWYPLGR VTGGTLYPGL MTTSAFIWHA LRNWLGLPID IRNVCVLFAP 120
  121 LFSGVTAWAT YEFTKEIKDA SAGLLAAGFI AIVPGYISRS VAGSYDNEAI AITLLMVTFM 180
  181 FWIKAQKTGS IMHATCAALF YFYMVSAWGG YVFITNLIPL HVFLLILMGR YSSKLYSAYT 240
  241 TWYAIGTVAS MQIPFVGFLP IRSNDHMAAL GVFGLIQIVA FGDFVKGQIS TAKFKVIMMV 300
  301 SLFLILVLGV VGLSALTYMG LIAPWTGRFY SLWDTNYAKI HIPIIASVSE HQPVSWPAFF 360
  361 FDTHFLIWLF PAGVFLLFLD LKDEHVFVIA YSVLCSYFAG VMVRLMLTLT PVICVSAAVA 420
  421 LSKIFDIYLD FKTSDRKYAI KPAALLAKLI VSGSFIFYLY LFVFHSTWVT RTAYSSPSVV 480
  481 LPSQTPDGKL ALIDDFREAY YWLRMNSDED SKVAAWWDYG YQIGGMADRT TLVDNNTWNN 540
  541 THIAIVGKAM ASPEEKSYEI LKEHDVDYVL VIFGGLIGFG GDDINKFLWM IRISEGIWPE 600
  601 EIKERDFYTA EGEYRVDARA SETMRNSLLY KMSYKDFPQL FNGGQATDRV RQQMITPLDV 660
  661 PPLDYFDEVF TSENWMVRIY QLKKDDAQGR TLRDVGELTR SSTKTRRSIK RPELGLRV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OST1 STT3
    View Details (MIPS) Mewes HW, et al. (2004) OST1 OST2 OST3 OST4 OST5 OST6 STT3 SWP1 WBP1
    View Details Krogan NJ, et al. (2006) ASN2 STT3 URA7
    View Details Gavin AC, et al. (2006) OST1 STT3 SWP1 WBP1
    View Details Gavin AC, et al. (2002) ERO1 OST1 OST6 SEC13 SEH1 STT3 SWP1 TIF34 WBP1
    View Details Qiu et al. (2008) ALG13 ALG2 ALG5 DIE2 DPM1 GWT1 OST1 OST2 OST3 OST4 OST5 OST6 PMT1 PMT3 SEC61 STT3 SWP1 WBP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data STT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..660] Pfam 279.070581 Oligosaccharyl transferase STT3 subunit No confident structure predictions are available.
    2 View Details [661..718] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle