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Protein Overview: OST1

General Information:
Name(s) found: OST1 / YJL002C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: oligosaccharyltransferase complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: protein amino acid N-linked glycosylation [IDALink to PubMed article]
    protein amino acid N-linked glycosylation via asparagine [IPILink to PubMed article]
    Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQVWFSWIV GLFLCFFNVS SAAQYEPPAT WENVDYKRTI DVSNAYISET IEITIKNIAS  60
   61 EPATEYFTAF ESGIFSKVSF FSAYFTNEAT FLNSQLLANS TTAPGDDGES EIRYGIIQFP 120
  121 NAISPQEEVS LVIKSFYNTV GIPYPEHVGM SEEQHLLWET NRLPLSAYDT KKASFTLIGS 180
  181 SSFEEYHPPN DESLLGKANG NSFEFGPWED IPRFSSNETL AIVYSHNAPL NQVVNLRRDI 240
  241 WLSHWASTIQ FEEYYELTNK AAKLSKGFSR LELMKQIQTQ NMRQTHFVTV LDMLLPEGAT 300
  301 DHYFTDLVGL VSTSHAERDH FFIRPRFPIF GGWNYNFTVG WTNKLSDFLH VSSGSDEKFV 360
  361 ASIPILNGPP DTVYDNVELS VFLPEGAEIF DIDSPVPFTN VSIETQKSYF DLNKGHVKLT 420
  421 FSYRNLISQV ANGQVLIKYD YPKSSFFKKP LSIACYIFTA LMGVFVLKTL NMNVTN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OST1 STT3
    View Details (MIPS) Mewes HW, et al. (2004) OST1 OST2 OST3 OST4 OST5 OST6 STT3 SWP1 WBP1
    View Details Gavin AC, et al. (2006) OST1 STT3 SWP1 WBP1
    View Details Gavin AC, et al. (2002) ERO1 OST1 OST6 SEC13 SEH1 STT3 SWP1 TIF34 WBP1
    View Details Qiu et al. (2008) ALG2 ALG8 OST1 OST2 OST3 OST4 OST5 OST6 STT3 SWP1 WBP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data OST1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] MSA 1.011986 View MSA. Confident ab initio structure predictions are available.
    2 View Details [110..293] deduced N/A No confident structure predictions are available.
    3 View Details [294..476] MSA 2.014964 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle