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Protein Overview: ALG2

General Information:
Name(s) found: ALG2 / YGL065C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TASLink to PubMed article]
    Biological Process: oligosaccharide-lipid intermediate assembly [TASLink to PubMed article]
    Molecular Function: glycolipid mannosyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEKDKRTIA FIHPDLGIGG AERLVVDAAL GLQQQGHSVI IYTSHCDKSH CFEEVKNGQL  60
   61 KVEVYGDFLP TNFLGRFFIV FATIRQLYLV IQLILQKKVN AYQLIIIDQL STCIPLLHIF 120
  121 SSATLMFYCH FPDQLLAQRA GLLKKIYRLP FDLIEQFSVS AADTVVVNSN FTKNTFHQTF 180
  181 KYLSNDPDVI YPCVDLSTIE IEDIDKKFFK TVFNEGDRFY LSINRFEKKK DVALAIKAFA 240
  241 LSEDQINDNV KLVICGGYDE RVAENVEYLK ELQSLADEYE LSHTTIYYQE IKRVSDLESF 300
  301 KTNNSKIIFL TSISSSLKEL LLERTEMLLY TPAYEHFGIV PLEAMKLGKP VLAVNNGGPL 360
  361 ETIKSYVAGE NESSATGWLK PAVPIQWATA IDESRKILQN GSVNFERNGP LRVKKYFSRE 420
  421 AMTQSFEENV EKVIWKEKKY YPWEIFGISF SNFILHMAFI KILPNNPWPF LFMATFMVLY 480
  481 FKNYLWGIYW AFVFALSYPY EEI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG1 ALG13 ALG2 ALG8 ALG9 OST1 PMT1 PMT3 PMT4 STT3 WBP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ALG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127]
    [419..503]    		 ORFEUS 10.52 UDP-glucosyltransferase GtfB
    2 View Details [128..198]
    [414..418]    		 ORFEUS 10.52 UDP-glucosyltransferase GtfB
    3 View Details [199..413] ORFEUS 10.52 UDP-glucosyltransferase GtfB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alpha-1,3-mannosyltransferase activity
    		•  6.58172475060696 bayes_pls_golite062009
  • glycolipid mannosyltransferase activity
    		•  5.39233021873725 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  3.21859657603001 bayes_pls_golite062009
  • glycolipid 6-alpha-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • glycolipid 3-alpha-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • alpha-1,6-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity
    		•  2.6268567881241 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • glycogen phosphorylase activity
    		•  1.55216954018473 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  1.5162351691061 bayes_pls_golite062009
  • binding
    		•  1.22341386111754 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  1.21599854394093 bayes_pls_golite062009
  • phosphorylase activity
    		•  1.16838250569299 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.354187614795831 bayes_pls_golite062009
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  0.333194028937286 bayes_pls_golite062009
  • protein binding
    		•  0.0755094482594821 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  4.32270241054966E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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