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Protein Overview: ALG1

General Information:
Name(s) found: ALG1 / YBR110W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 449 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IPILink to PubMed article]
    Biological Process: oligosaccharide-lipid intermediate assembly [IMPLink to PubMed article]
    protein amino acid N-linked glycosylation [IMPLink to PubMed article]
    Molecular Function: beta-1,4-mannosyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLEIPRWLL ALIILYLSIP LVVYYVIPYL FYGNKSTKKR IIIFVLGDVG HSPRICYHAI  60
   61 SFSKLGWQVE LCGYVEDTLP KIISSDPNIT VHHMSNLKRK GGGTSVIFMV KKVLFQVLSI 120
  121 FKLLWELRGS DYILVQNPPS IPILPIAVLY KLTGCKLIID WHNLAYSILQ LKFKGNFYHP 180
  181 LVLISYMVEM IFSKFADYNL TVTEAMRKYL IQSFHLNPKR CAVLYDRPAS QFQPLAGDIS 240
  241 RQKALTTKAF IKNYIRDDFD TEKGDKIIVT STSFTPDEDI GILLGALKIY ENSYVKFDSS 300
  301 LPKILCFITG KGPLKEKYMK QVEEYDWKRC QIEFVWLSAE DYPKLLQLCD YGVSLHTSSS 360
  361 GLDLPMKILD MFGSGLPVIA MNYPVLDELV QHNVNGLKFV DRRELHESLI FAMKDADLYQ 420
  421 KLKKNVTQEA ENRWQSNWER TMRDLKLIH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG1 ALG2 ALG6 ALG8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ALG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 6.69897 Peptidoglycan biosynthesys glycosyltransferase MurG
    2 View Details [225..390] PSI-BLAST 6.69897 Peptidoglycan biosynthesys glycosyltransferase MurG
    3 View Details [391..449] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycolipid mannosyltransferase activity
    		•  5.39233021873725 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  3.21859657603001 bayes_pls_golite062009
  • glycolipid 6-alpha-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • glycolipid 3-alpha-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • alpha-1,6-mannosyltransferase activity
    		•  2.81514353203234 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity
    		•  2.6268567881241 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • alpha-1,3-mannosyltransferase activity
    		•  2.61939274100154 bayes_pls_golite062009
  • glycogen phosphorylase activity
    		•  2.3376682145987 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  2.11024512158394 bayes_pls_golite062009
  • protein anchor
    		•  1.99520345594672 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  1.84595685206241 bayes_pls_golite062009
  • UDP-N-acetylglucosamine 2-epimerase activity
    		•  1.55280519670033 bayes_pls_golite062009
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  0.849686864309466 bayes_pls_golite062009
  • binding
    		•  0.399722153246393 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.354187614795831 bayes_pls_golite062009
  • phosphorylase activity
    		•  0.296436712681472 bayes_pls_golite062009
  • protein binding
    		•  0.198267161626932 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  4.32270241054966E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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