YRC Public Data Repository - Protein Structure Prediction

Protein:	ALG1
Organism:	Saccharomyces cerevisiae
Length:	449 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALG1.

Description	E-value	Query Range	Subject Range
ALG1 - Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); ... ALG1_YEAST - Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450...	7.0E-79	[1..445]	[1..445]
gi\|16605573, gi\|... - gi\|23127948\|ref\|ZP_00109805.1\| COG0438: Glycosyltransferase [Nostoc punctiforme PCC 73102], gi\|18668... gi\|16605573 - gi\|16605573\|emb\|CAC87824.1\| putative sucrose-phosphate synthase [Nostoc punctiforme PCC 73102]	1.0E-67	[34..449]	[2..406]
Y1607_METJA, YG0... - (Q59002) Hypothetical glycosyl transferase MJ1607 (EC 2.-.-.-), Uncharacterized glycosyltransferase ... Y1607_METJA - Uncharacterized glycosyltransferase MJ1607 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM...	2.0E-66	[40..449]	[2..381]
gi\|17230862, gi\|... - gi\|17230862\|ref\|NP_487410.1\| hypothetical protein alr3370 [Nostoc sp. PCC 7120], gi\|17132465\|dbj\|BAB... gi\|25530845 - pir\|\|AC2227 hypothetical protein alr3370 [imported] - Nostoc sp. (strain PCC 7120)	2.0E-66	[35..449]	[7..410]
MSHA_CORGL - D-inositol-3-phosphate glycosyltransferase OS=Corynebacterium glutamicum GN=mshA PE=1 SV=1 MSHA_CORGL - D-inositol 3-phosphate glycosyltransferase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20... MSHA_CORGB - D-inositol 3-phosphate glycosyltransferase OS=Corynebacterium glutamicum (strain R) GN=mshA PE=3 SV=...	1.0E-64	[50..449]	[23..402]
gi\|25489849 - pir\|\|G83826 hypothetical protein BH1415 [imported] - Bacillus halodurans (strain C-125) gi\|10174032, gi\|... - gi\|15613978\|ref\|NP_242281.1\| hypothetical protein BH1415 [Bacillus halodurans C-125], gi\|10174032\|db...	2.0E-62	[50..448]	[553..912]
SPSA_SOLTU - Probable sucrose-phosphate synthase OS=Solanum tuberosum GN=SPS PE=2 SV=1	5.0E-62	[50..447]	[192..664]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLEIPRWLL ALIILYLSIP LVVYYVIPYL FYGNKSTKKR IIIFVLGDVG HSPRICYHAI  60
   61 SFSKLGWQVE LCGYVEDTLP KIISSDPNIT VHHMSNLKRK GGGTSVIFMV KKVLFQVLSI 120
  121 FKLLWELRGS DYILVQNPPS IPILPIAVLY KLTGCKLIID WHNLAYSILQ LKFKGNFYHP 180
  181 LVLISYMVEM IFSKFADYNL TVTEAMRKYL IQSFHLNPKR CAVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1f0kA_
Description:	Peptidoglycan biosynthesys glycosyltransferase MurG
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glycolipid mannosyltransferase activity	5.39233021873725	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	3.70184884300914	bayes_pls_golite062009
mannosyltransferase activity	3.21859657603001	bayes_pls_golite062009
glycolipid 6-alpha-mannosyltransferase activity	2.81514353203234	bayes_pls_golite062009
glycolipid 3-alpha-mannosyltransferase activity	2.81514353203234	bayes_pls_golite062009
alpha-1,6-mannosyltransferase activity	2.81514353203234	bayes_pls_golite062009
catalytic activity	2.65148466065976	bayes_pls_golite062009
transferase activity	2.6268567881241	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.62403914335522	bayes_pls_golite062009
alpha-1,3-mannosyltransferase activity	2.61939274100154	bayes_pls_golite062009
glycogen phosphorylase activity	2.3376682145987	bayes_pls_golite062009
UDP-glycosyltransferase activity	2.13085705769565	bayes_pls_golite062009
glucosyltransferase activity	2.11024512158394	bayes_pls_golite062009
protein anchor	1.99520345594672	bayes_pls_golite062009
UDP-glucosyltransferase activity	1.84595685206241	bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity	1.55280519670033	bayes_pls_golite062009
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	0.849686864309466	bayes_pls_golite062009
binding	0.399722153246393	bayes_pls_golite062009
acetylglucosaminyltransferase activity	0.354187614795831	bayes_pls_golite062009
phosphorylase activity	0.296436712681472	bayes_pls_golite062009
protein binding	0.198267161626932	bayes_pls_golite062009
carbohydrate phosphatase activity	4.32270241054966E-4	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [225-390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDRPASQFQP LAGDISRQKA LTTKAFIKNY IRDDFDTEKG DKIIVTSTSF TPDEDIGILL  60
   61 GALKIYENSY VKFDSSLPKI LCFITGKGPL KEKYMKQVEE YDWKRCQIEF VWLSAEDYPK 120
  121 LLQLCDYGVS LHTSSSGLDL PMKILDMFGS GLPVIAMNYP VLDELV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1f0kA_
Description:	Peptidoglycan biosynthesys glycosyltransferase MurG
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [391-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHNVNGLKFV DRRELHESLI FAMKDADLYQ KLKKNVTQEA ENRWQSNWER TMRDLKLIH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: