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Protein Overview: ALG6

General Information:
Name(s) found: ALG6 / YOR002W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IMPLink to PubMed article]
    Biological Process: protein amino acid glycosylation [IMPLink to PubMed article]
    dolichol-linked oligosaccharide biosynthetic process [TASLink to PubMed article]
    Molecular Function: transferase activity, transferring hexosyl groups [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIGKRLLVN KPAEESFYAS PMYDFLYPFR PVGNQWLPEY IIFVCAVILR CTIGLGPYSG  60
   61 KGSPPLYGDF EAQRHWMEIT QHLPLSKWYW YDLQYWGLDY PPLTAFHSYL LGLIGSFFNP 120
  121 SWFALEKSRG FESPDNGLKT YMRSTVIISD ILFYFPAVIY FTKWLGRYRN QSPIGQSIAA 180
  181 SAILFQPSLM LIDHGHFQYN SVMLGLTAYA INNLLDEYYA MAAVCFVLSI CFKQMALYYA 240
  241 PIFFAYLLSR SLLFPKFNIA RLTVIAFATL ATFAIIFAPL YFLGGGLKNI HQCIHRIFPF 300
  301 ARGIFEDKVA NFWCVTNVFV KYKERFTIQQ LQLYSLIATV IGFLPAMIMT LLHPKKHLLP 360
  361 YVLIACSMSF FLFSFQVHEK TILIPLLPIT LLYSSTDWNV LSLVSWINNV ALFTLWPLLK 420
  421 KDGLHLQYAV SFLLSNWLIG NFSFITPRFL PKSLTPGPSI SSINSDYRRR SLLPYNVVWK 480
  481 SFIIGTYIAM GFYHFLDQFV APPSKYPDLW VLLNCAVGFI CFSIFWLWSY YKIFTSGSKS 540
  541 MKDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG1 ALG12 ALG13 ALG6 ALG8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ALG6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..544] Pfam 288.431798 ALG6, ALG8 glycosyltransferase family No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle