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View Structure Prediction Details

Protein: ALG2
Organism: Saccharomyces cerevisiae
Length: 503 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALG2.

Description E-value Query
Range		 Subject
Range
ALG2 - Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2...
ALG2_YEAST - Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=A...
 0.0 [1..503] [1..503]
SUS2_PEA - Sucrose synthase 2 OS=Pisum sativum GN=SUS2 PE=2 SV=1
 1.0E-78 [10..454] [294..801]
gi|6682841 - gi|6682841|dbj|BAA88904.1| sucrose synthase [Citrus unshiu]
 3.0E-78 [10..455] [293..801]
SUS1_ORYSJ - Sucrose synthase 1 OS=Oryza sativa subsp. japonica GN=SUS1 PE=1 SV=1
SUS2_ORYSA - Sucrose synthase 2 (EC 2.4.1.13) (Sucrose-UDP glucosyltransferase 2) - Oryza sativa (Rice)
 4.0E-78 [10..454] [296..802]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-77 [10..454] [296..802]
SUSY_VIGRR - Sucrose synthase OS=Vigna radiata var. radiata GN=SS1 PE=1 SV=1
gi|218333 - gi|218333|dbj|BAA01108.1| sucrose synthase [Vigna radiata]
 2.0E-77 [12..454] [293..797]
SUS2_TULGE - Sucrose synthase 2 OS=Tulipa gesneriana PE=2 SV=1
 2.0E-77 [10..455] [292..799]
SUSY_SOYBN - Sucrose synthase OS=Glycine max GN=SS PE=1 SV=2
 3.0E-77 [12..454] [293..797]

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Predicted Domain #1
Region A:
Residues: [1-127] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEKDKRTIA FIHPDLGIGG AERLVVDAAL GLQQQGHSVI IYTSHCDKSH CFEEVKNGQL  60
   61 KVEVYGDFLP TNFLGRFFIV FATIRQLYLV IQLILQKKVN AYQLIIIDQL STCIPLLHIF 120
  121 SSATLMF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [419-503] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REAMTQSFEE NVEKVIWKEK KYYPWEIFGI SFSNFILHMA FIKILPNNPW PFLFMATFMV  60
   61 LYFKNYLWGI YWAFVFALSY PYEEI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.52
Match: 1iirA
Description: UDP-glucosyltransferase GtfB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
alpha-1,3-mannosyltransferase activity 6.58172475060696 bayes_pls_golite062009
glycolipid mannosyltransferase activity 5.39233021873725 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
mannosyltransferase activity 3.21859657603001 bayes_pls_golite062009
glycolipid 6-alpha-mannosyltransferase activity 2.81514353203234 bayes_pls_golite062009
glycolipid 3-alpha-mannosyltransferase activity 2.81514353203234 bayes_pls_golite062009
alpha-1,6-mannosyltransferase activity 2.81514353203234 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity 2.6268567881241 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
glycogen phosphorylase activity 1.55216954018473 bayes_pls_golite062009
glucosyltransferase activity 1.5162351691061 bayes_pls_golite062009
binding 1.22341386111754 bayes_pls_golite062009
UDP-glucosyltransferase activity 1.21599854394093 bayes_pls_golite062009
phosphorylase activity 1.16838250569299 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.354187614795831 bayes_pls_golite062009
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 0.333194028937286 bayes_pls_golite062009
protein binding 0.0755094482594821 bayes_pls_golite062009
carbohydrate phosphatase activity 4.32270241054966E-4 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [128-198] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YCHFPDQLLA QRAGLLKKIY RLPFDLIEQF SVSAADTVVV NSNFTKNTFH QTFKYLSNDP  60
   61 DVIYPCVDLS T

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [414-418] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKYFS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.52
Match: 1iirA
Description: UDP-glucosyltransferase GtfB
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [199-413] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEIEDIDKKF FKTVFNEGDR FYLSINRFEK KKDVALAIKA FALSEDQIND NVKLVICGGY  60
   61 DERVAENVEY LKELQSLADE YELSHTTIYY QEIKRVSDLE SFKTNNSKII FLTSISSSLK 120
  121 ELLLERTEML LYTPAYEHFG IVPLEAMKLG KPVLAVNNGG PLETIKSYVA GENESSATGW 180
  181 LKPAVPIQWA TAIDESRKIL QNGSVNFERN GPLRV

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.52
Match: 1iirA
Description: UDP-glucosyltransferase GtfB
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle