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Protein Overview: PMT4

General Information:
Name(s) found: PMT4 / YJR143C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 762 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TASLink to PubMed article]
    Biological Process: protein amino acid O-linked glycosylation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: dolichyl-phosphate-mannose-protein mannosyltransferase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPKKRNHG KLPPSTKDVD DPSLKYTKAA PKCEQVAEHW LLQPLPEPES RYSFWVTIVT  60
   61 LLAFAARFYK IWYPKEVVFD EVHFGKFASY YLERSYFFDV HPPFAKMMIA FIGWLCGYDG 120
  121 SFKFDEIGYS YETHPAPYIA YRSFNAILGT LTVPIMFNTL KELNFRAITC AFASLLVAID 180
  181 TAHVTETRLI LLDAILIISI AATMYCYVRF YKCQLRQPFT WSWYIWLHAT GLSLSFVIST 240
  241 KYVGVMTYSA IGFAAVVNLW QLLDIKAGLS LRQFMRHFSK RLNGLVLIPF VIYLFWFWVH 300
  301 FTVLNTSGPG DAFMSAEFQE TLKDSPLSVD SKTVNYFDII TIKHQDTDAF LHSHLARYPQ 360
  361 RYEDGRISSA GQQVTGYTHP DFNNQWEVLP PHGSDVGKGQ AVLLNQHIRL RHVATDTYLL 420
  421 AHDVASPFYP TNEEITTVTL EEGDGELYPE TLFAFQPLKK SDEGHVLKSK TVSFRLFHVD 480
  481 TSVALWTHND ELLPDWGFQQ QEINGNKKVI DPSNNWVVDE IVNLDEVRKV YIPKVVKPLP 540
  541 FLKKWIETQK SMFEHNNKLS SEHPFASEPY SWPGSLSGVS FWTNGDEKKQ IYFIGNIIGW 600
  601 WFQVISLAVF VGIIVADLIT RHRGYYALNK MTREKLYGPL MFFFVSWCCH YFPFFLMARQ 660
  661 KFLHHYLPAH LIACLFSGAL WEVIFSDCKS LDLEKDEDIS GASYERNPKV YVKPYTVFLV 720
  721 CVSCAVAWFF VYFSPLVYGD VSLSPSEVVS REWFDIELNF SK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACK1 CIN8 DCG1 GNA1 MCM6 MLP1 PMD1 PMT4 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RFT1 SCL1 SGA1 SNQ2 TOS8 UMP1 YCR076C YDR179W-A YJL132W YKR070W YLR211C YLR290C
    View Details Qiu et al. (2008) ALG2 PMT1 PMT2 PMT3 PMT4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PMT4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..322] Pfam 98.251812 Dolichyl-phosphate-mannose-protein mannosyltransferase No confident structure predictions are available.
    2 View Details [323..391] Pfam 11.79588 MIR domain No confident structure predictions are available.
    3 View Details [392..538] ORFEUS 10.63 IP3 receptor type 1 binding core, domain 2; IP3 receptor type 1 binding core, domain 1
    4 View Details [539..611] deduced N/A No confident structure predictions are available.
    5 View Details [612..762] MSA 1.028973 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    		•  7.33543412640964 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  6.32966341675541 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.60661923349025 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.57555885876017 bayes_pls_golite062009
  • receptor activity
    		•  1.99332745476324 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • signal transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • cation channel activity
    		•  1.66500687404195 bayes_pls_golite062009
  • ion channel activity
    		•  1.61859406934521 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.57127083095499 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.55374970486978 bayes_pls_golite062009
  • channel activity
    		•  1.55374970486978 bayes_pls_golite062009
  • inositol-1,4,5-trisphosphate receptor activity
    		•  1.28298370923705 bayes_pls_golite062009
  • transferase activity
    		•  0.981084601370981 bayes_pls_golite062009
  • calcium channel activity
    		•  0.85901349040585 bayes_pls_golite062009
  • catalytic activity
    		•  0.659936859803906 bayes_pls_golite062009
  • calcium-release channel activity
    		•  0.65133561512386 bayes_pls_golite062009
  • gated channel activity
    		•  0.53737429019655 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • protein binding
    		•  0.405144403982597 bayes_pls_golite062009
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
    		•  0.152598505509111 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle