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Protein Overview: PMT2

General Information:
Name(s) found: PMT2 / YAL023C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TASLink to PubMed article]
    Biological Process: protein amino acid O-linked glycosylation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: dolichyl-phosphate-mannose-protein mannosyltransferase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSSTGYS KNNAAHIKQE NTLRQRESSS ISVSEELSSA DERDAEDFSK EKPAAQSSLL  60
   61 RLESVVMPVI FTALALFTRM YKIGINNHVV WDEAHFGKFG SYYLRHEFYH DVHPPLGKML 120
  121 VGLSGYLAGY NGSWDFPSGE IYPDYLDYVK MRLFNASFSA LCVPLAYFTA KAIGFSLPTV 180
  181 WLMTVLVLFE NSYSTLGRFI LLDSMLLFFT VASFFSFVMF HNQRSKPFSR KWWKWLLITG 240
  241 ISLGCTISVK MVGLFIITMV GIYTVIDLWT FLADKSMSWK TYINHWLARI FGLIIVPFCI 300
  301 FLLCFKIHFD LLSHSGTGDA NMPSLFQARL VGSDVGQGPR DIALGSSVVS IKNQALGGSL 360
  361 LHSHIQTYPD GSNQQQVTCY GYKDANNEWF FNRERGLPSW SENETDIEYL KPGTSYRLVH 420
  421 KSTGRNLHTH PVAAPVSKTQ WEVSGYGDNV VGDNKDNWVI EIMDQRGDED PEKLHTLTTS 480
  481 FRIKNLEMGC YLAQTGNSLP EWGFRQQEVV CMKNPFKRDK RTWWNIETHE NERLPPRPED 540
  541 FQYPKTNFLK DFIHLNLAMM ATNNALVPDP DKFDYLASSA WQWPTLNVGL RLCGWGDDNP 600
  601 KYFLLGTPAS TWASSVAVLA FMATVVILLI RWQRQYVDLR NPSNWNVFLM GGFYPLLAWG 660
  661 LHYMPFVIMS RVTYVHHYLP ALYFALIILA YCFDAGLQKW SRSKCGRIMR FVLYAGFMAL 720
  721 VIGCFWYFSP ISFGMEGPSS NFRYLNWFST WDIADKQEA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ANP1 PMT2 YCR043C
    View Details Qiu et al. (2008) ALG9 DPM1 PMT1 PMT2 PMT3 PMT4 PMT6

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PMT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] MSA 1.382992 View MSA. No confident structure predictions are available.
    2 View Details [111..311] MSA 4.397996 View MSA. No confident structure predictions are available.
    3 View Details [312..407] Pfam 13.39794 No description for PF02815.7 was found. No confident structure predictions are available.
    4 View Details [408..467] Pfam 15.004365 No description for PF02815.7 was found. No confident structure predictions are available.
    5 View Details [468..536] Pfam 17.920819 No description for PF02815.7 was found. No confident structure predictions are available.
    6 View Details [537..759] MSA 2.23798 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    		•  7.33543412640964 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  6.32966341675541 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.60661923349025 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.57555885876017 bayes_pls_golite062009
  • receptor activity
    		•  1.99332745476324 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • signal transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • cation channel activity
    		•  1.66500687404195 bayes_pls_golite062009
  • ion channel activity
    		•  1.61859406934521 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.57127083095499 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.55374970486978 bayes_pls_golite062009
  • channel activity
    		•  1.55374970486978 bayes_pls_golite062009
  • inositol-1,4,5-trisphosphate receptor activity
    		•  1.28298370923705 bayes_pls_golite062009
  • transferase activity
    		•  0.981084601370981 bayes_pls_golite062009
  • calcium channel activity
    		•  0.85901349040585 bayes_pls_golite062009
  • catalytic activity
    		•  0.659936859803906 bayes_pls_golite062009
  • calcium-release channel activity
    		•  0.65133561512386 bayes_pls_golite062009
  • gated channel activity
    		•  0.53737429019655 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • protein binding
    		•  0.405144403982597 bayes_pls_golite062009
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
    		•  0.152598505509111 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle