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Protein Overview: PMT1

General Information:
Name(s) found: PMT1 / YDL095W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; one of seven related proteins involved in O-glycosylation which is essential for cell wall rigidity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    Biological Process: protein amino acid O-linked glycosylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: dolichyl-phosphate-mannose-protein mannosyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEKTYKRV EQDDPVPELD IKQGPVRPFI VTDPSAELAS LRTMVTLKEK LLVACLAVFT  60
   61 AVIRLHGLAW PDSVVFDEVH FGGFASQYIR GTYFMDVHPP LAKMLYAGVA SLGGFQGDFD 120
  121 FENIGDSFPS TTPYVLMRFF SASLGALTVI LMYMTLRYSG VRMWVALMSA ICFAVENSYV 180
  181 TISRYILLDA PLMFFIAAAV YSFKKYEMYP ANSLNAYKSL LATGIALGMA SSSKWVGLFT 240
  241 VTWVGLLCIW RLWFMIGDLT KSSKSIFKVA FAKLAFLLGV PFALYLVFFY IHFQSLTLDG 300
  301 DGASFFSPEF RSTLKNNKIP QNVVADVGIG SIISLRHLST MGGYLHSHSH NYPAGSEQQQ 360
  361 STLYPHMDAN NDWLLELYNA PGESLTTFQN LTDGTKVRLF HTVTRCRLHS HDHKPPVSES 420
  421 SDWQKEVSCY GYSGFDGDAN DDWVVEIDKK NSAPGVAQER VIALDTKFRL RHAMTGCYLF 480
  481 SHEVKLPAWG FEQQEVTCAS SGRHDLTLWY VENNSNPLLP EDTKRISYKP ASFISKFIES 540
  541 HKKMWHINKN LVEPHVYESQ PTSWPFLLRG ISYWGENNRN VYLLGNAIVW WAVTAFIGIF 600
  601 GLIVITELFS WQLGKPILKD SKVVNFHVQV IHYLLGFAVH YAPSFLMQRQ MFLHHYLPAY 660
  661 YFGILALGHA LDIIVSYVFR SKRQMGYAVV ITFLAASVYF FKSFSPIIYG TPWTQELCQK 720
  721 SQWLSGWDYN CNTYFSSLEE YKNQTLTKRE SQPAATSTVE EITIEGDGPS YEDLMNEDGK 780
  781 KIFKDTEGNE LDPEVVKKML EEEGANILKV EKRAVLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GPD1 PDR5 PHO86 PMA1 PMT1 SSH1 WBP1 YGR266W
    View Details Qiu et al. (2008) ALG2 ALG5 DPM1 PMT1 PMT2 PMT3 PMT4 STT3 WBP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PMT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..319] Pfam 100.619789 Dolichyl-phosphate-mannose-protein mannosyltransferase No confident structure predictions are available.
    2 View Details [320..384] Pfam 16.0 MIR domain No confident structure predictions are available.
    3 View Details [385..457] Pfam 19.823909 MIR domain No confident structure predictions are available.
    4 View Details [458..547] Pfam 19.508638 MIR domain No confident structure predictions are available.
    5 View Details [548..602] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [603..743] MSA 1.032972 View MSA. No confident structure predictions are available.
    7 View Details [744..817] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    		•  7.33543412640964 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  6.32966341675541 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.60661923349025 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.57555885876017 bayes_pls_golite062009
  • receptor activity
    		•  1.99332745476324 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • signal transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • cation channel activity
    		•  1.66500687404195 bayes_pls_golite062009
  • ion channel activity
    		•  1.61859406934521 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.57127083095499 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.55374970486978 bayes_pls_golite062009
  • channel activity
    		•  1.55374970486978 bayes_pls_golite062009
  • inositol-1,4,5-trisphosphate receptor activity
    		•  1.28298370923705 bayes_pls_golite062009
  • transferase activity
    		•  0.981084601370981 bayes_pls_golite062009
  • calcium channel activity
    		•  0.85901349040585 bayes_pls_golite062009
  • catalytic activity
    		•  0.659936859803906 bayes_pls_golite062009
  • calcium-release channel activity
    		•  0.65133561512386 bayes_pls_golite062009
  • gated channel activity
    		•  0.53737429019655 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • protein binding
    		•  0.405144403982597 bayes_pls_golite062009
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
    		•  0.152598505509111 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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