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View Structure Prediction Details

Protein: SEC63
Organism: Saccharomyces cerevisiae
Length: 663 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC63.

Description E-value Query
Range
Subject
Range
gi|4045 - gi|4045|emb|CAA34424.1| unnamed protein product [Saccharomyces cerevisiae]
0.0 [1..663] [1..663]
SEC63_SCHPO - Translocation protein sec63 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sec63 PE=1 SV=...
sec63 - ER protein translocation subcomplex subunit Sec63
0.0 [1..654] [1..607]
DNJ29_ARATH - DnaJ protein ERDJ2B OS=Arabidopsis thaliana GN=ERDJ2B PE=1 SV=1
0.0 [6..615] [3..605]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [22..615] [1..592]
gi|209180421 - gi|209180421|ref|NP_001126607.1| SEC63 homolog [Pongo abelii]
SEC63 - SEC63 homolog (S. cerevisiae)
gi|109072241 - gi|109072241|ref|XP_001092234.1| PREDICTED: SEC63-like protein isoform 4 [Macaca mulatta]
0.0 [5..487] [6..508]
SEC63_MOUSE - Translocation protein SEC63 homolog OS=Mus musculus GN=Sec63 PE=1 SV=3
2.0E-99 [5..488] [6..509]

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Predicted Domain #1
Region A:
Residues: [1-116]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTNYEYDEA SETWPSFILT GLLMVVGPMT LLQIYQIFFG ANAEDGNSGK SKEFNEEVFK  60
   61 NLNEEYTSDE IKQFRRKFDK NSNKKSKIWS RRNIIIIVGW ILVAILLQRI NSNDAI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [117-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDAATKLFDP YEILGISTSA SDRDIKSAYR KLSVKFHPDK LAKGLTPDEK SVMEETYVQI  60
   61 TKAYESLTDE LVRQNYLKYG HPDGPQSTSH GIALPRFLVD GSASPLLVVC YVALLGLILP 120
  121 YFVSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 127.502279
Match: 1xbl__
Description: DnaJ chaperone, N-terminal (J) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal recognition particle binding 3.28103883404258 bayes_pls_golite062009
ribonucleoprotein binding 2.20695097776982 bayes_pls_golite062009
protein binding 2.0077819170005 bayes_pls_golite062009
binding 1.75184008862922 bayes_pls_golite062009
transporter activity 1.29863098651348 bayes_pls_golite062009
Hsp70 protein binding 1.13087926351787 bayes_pls_golite062009
protein transporter activity 0.939490372372376 bayes_pls_golite062009
unfolded protein binding 0.91241047562027 bayes_pls_golite062009
substrate-specific transporter activity 0.812144232432417 bayes_pls_golite062009
heat shock protein binding 0.796066295738949 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [242-663]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWARTQSYTK KGIHNVTASN FVSNLVNYKP SEIVTTDLIL HWLSFAHEFK QFFPDLQPTD  60
   61 FEKLLQDHIN RRDSGKLNNA KFRIVAKCHS LLHGLLDIAC GFRNLDIALG AINTFKCIVQ 120
  121 AVPLTPNCQI LQLPNVDKEH FITKTGDIHT LGKLFTLEDA KIGEVLGIKD QAKLNETLRV 180
  181 ASHIPNLKII KADFLVPGEN QVTPSSTPYI SLKVLVRSAK QPLIPTSLIP EENLTEPQDF 240
  241 ESQRDPFAMM SKQPLVPYSF APFFPTKRRG SWCCLVSSQK DGKILQTPII IEKLSYKNLN 300
  301 DDKDFFDKRI KMDLTKHEKF DINDWEIGTI KIPLGQPAPE TVGDFFFRVI VKSTDYFTTD 360
  361 LDITMNMKVR DSPAVEQVEV YSEEDDEYST DDDETESDDE SDASDYTDID TDTEAEDDES 420
  421 PE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transporter activity 2.46466249895824 bayes_pls_golite062009
voltage-gated cation channel activity 2.40264381204753 bayes_pls_golite062009
substrate-specific transporter activity 2.37642404692102 bayes_pls_golite062009
transmembrane transporter activity 2.37262306131842 bayes_pls_golite062009
potassium channel activity 2.35561670403632 bayes_pls_golite062009
voltage-gated potassium channel activity 2.33426249687556 bayes_pls_golite062009
voltage-gated ion channel activity 2.33102664959792 bayes_pls_golite062009
substrate-specific channel activity 2.32502571419352 bayes_pls_golite062009
voltage-gated channel activity 2.32465304131102 bayes_pls_golite062009
passive transmembrane transporter activity 2.3181005726144 bayes_pls_golite062009
channel activity 2.3181005726144 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.31677709260544 bayes_pls_golite062009
cation channel activity 2.30081429233977 bayes_pls_golite062009
ion transmembrane transporter activity 2.28077016868353 bayes_pls_golite062009
ion channel activity 2.2553711462771 bayes_pls_golite062009
cation transmembrane transporter activity 2.23522391314947 bayes_pls_golite062009
ATPase activity, coupled 2.2162185402774 bayes_pls_golite062009
gated channel activity 2.16810998541959 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.15379228421204 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.00003070639929 bayes_pls_golite062009
ATPase activity 1.94063929259701 bayes_pls_golite062009
pyrophosphatase activity 1.93031967085303 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.91231918357992 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.90999409453671 bayes_pls_golite062009
protein binding 1.90127097529706 bayes_pls_golite062009
inward rectifier potassium channel activity 1.86598930407084 bayes_pls_golite062009
ligand-gated channel activity 1.81486809950722 bayes_pls_golite062009
ligand-gated ion channel activity 1.81486809950722 bayes_pls_golite062009
binding 1.77589663168522 bayes_pls_golite062009
cytoskeletal protein binding 0.56566273004515 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.223800319644873 bayes_pls_golite062009
ATP-dependent helicase activity 0.223800319644873 bayes_pls_golite062009
helicase activity 0.166899434976303 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.0561411188724552 bayes_pls_golite062009
RNA-dependent ATPase activity 0.0447036496272264 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle