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Protein Overview: sec63

General Information:
Name(s) found: sec63 / SPBC36B7.03 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • ER protein translocation subcomplex subunit Sec63 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 611 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [ISSLink to PubMed article]
    Sec62/Sec63 complex [ISSLink to PubMed article]
    integral to membrane [IEA]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane [ISSLink to PubMed article]
    protein folding [RCALink to PubMed article]
    posttranslational protein targeting to membrane [ISSLink to PubMed article]
    Molecular Function: Hsp70 protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEYKYDEQ GIFFPVFLLV GTSCCVLPLT YSTILGPSAS KEKKNVRDPF QKYRPKDLKV  60
   61 QRKSIFRLRY IFLILGWLAI GFLSYKIANS RLKLNIWDPY EILGIAKGTS VDDVRRHYKR 120
  121 LSIKFHPDKV RNMVNTTREE VEKHYIEITN AYRALTDDKT RENYALYGTP DVPQHISVGI 180
  181 ALPKWISESE NSIYILGFYG LVFGIVLPYA VGKWWYGSRT YTRDHVHVDT VDEWFPKMET 240
  241 SLTLDELLSL FASSKELTSL VPNEKNPKEY ILKLLFDHLN RKKTNNFNTH QILSQSDVVL 300
  301 NALLSVATAF GFANPVDNVL KLWQHIVQAI PLDAPFPLLQ LPHLLMEDVK NLSIRNISSI 360
  361 PQFLSLSEEQ TKDYLPNYSK NQLKEMREIA NGIPRISVVA AKVLVDDDEY ITVGAIANLI 420
  421 LDLKCSYGTE VVPEVSTDGT ETATKKDEED AEKYHQSKDV VLGDVETLPY AWAPYFTQHH 480
  481 KTAWWIYVVD PRQNRVIVPP FSITDIPKTL RTFRIPFQVP PVAGTFSFQL HIMSNSYVGE 540
  541 DVISNLTMIV KDTSVLQEQL QEEAVSDLED NSDIDESANA GKDFSDDENI GSDEEDESEY 600
  601 DPMDTDTSDG E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] deduced N/A No confident structure predictions are available.
    2 View Details [95..217] PSI-BLAST 28.09691 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    3 View Details [218..611] PSI-BLAST 75.221849 No description for 2q0zX was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • signal recognition particle binding
    		•  3.28103883404258 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  2.20695097776982 bayes_pls_golite062009
  • protein binding
    		•  2.0077819170005 bayes_pls_golite062009
  • binding
    		•  1.75184008862922 bayes_pls_golite062009
  • transporter activity
    		•  1.29863098651348 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  1.13087926351787 bayes_pls_golite062009
  • protein transporter activity
    		•  0.939490372372376 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.91241047562027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.812144232432417 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.796066295738949 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transporter activity
    		•  2.46466249895824 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.40264381204753 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.37642404692102 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.37262306131842 bayes_pls_golite062009
  • potassium channel activity
    		•  2.35561670403632 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.33426249687556 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  2.33102664959792 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.32502571419352 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.32465304131102 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.3181005726144 bayes_pls_golite062009
  • channel activity
    		•  2.3181005726144 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.31677709260544 bayes_pls_golite062009
  • cation channel activity
    		•  2.30081429233977 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.28077016868353 bayes_pls_golite062009
  • ion channel activity
    		•  2.2553711462771 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.23522391314947 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.2162185402774 bayes_pls_golite062009
  • gated channel activity
    		•  2.16810998541959 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.15379228421204 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.00003070639929 bayes_pls_golite062009
  • ATPase activity
    		•  1.94063929259701 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.93031967085303 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.91231918357992 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.90999409453671 bayes_pls_golite062009
  • protein binding
    		•  1.90127097529706 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  1.86598930407084 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.81486809950722 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.81486809950722 bayes_pls_golite062009
  • binding
    		•  1.77589663168522 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.56566273004515 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.223800319644873 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.223800319644873 bayes_pls_golite062009
  • helicase activity
    		•  0.166899434976303 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.0561411188724552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.0447036496272264 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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