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Protein Overview: SSS1

General Information:
Name(s) found: SSS1 / YDR086C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 80 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    Sec61 translocon complex [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    posttranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    protein secretion [IMPLink to PubMed article]
    posttranslational protein targeting to membrane [TASLink to PubMed article]
    Molecular Function: protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARASEKGEE KKQSNNQVEK LVEAPVEFVR EGTQFLAKCK KPDLKEYTKI VKAVGIGFIA  60
   61 VGIIGYAIKL IHIPIRYVIV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) SBH1 SEC61 SSS1
    View Details Krogan NJ, et al. (2006) EMP24 ERP1 ERP2 KAR2 PHB2 SCJ1 SSS1 YEL1
    View Details Qiu et al. (2008) SBH1 SBH2 SEC61 SEC62 SEC63 SEC72 SRP102 SSH1 SSS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SSS1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] Pfam 21.920819 SecE/Sec61-gamma subunits of protein translocation complex No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle