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Protein Overview: SEC62

General Information:
Name(s) found: SEC62 / YPL094C [SGD]
Description(s) found:
Found 17 descriptions.
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  • Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 274 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    Sec62/Sec63 complex [IPILink to PubMed article]
    Biological Process: posttranslational protein targeting to membrane [TASLink to PubMed article]
    Molecular Function: protein binding [IMPLink to PubMed article][IPILink to PubMed article]
    protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVGPGSNA GASVNGGSAT AIATLLRNHK ELKQRQGLFQ AKQTDFFRYK RFVRALHSEE  60
   61 YANKSARQPE IYPTIPSNKI EDQLKSREIF IQLIKAQMVI PVKKLHSQEC KEHGLKPSKD 120
  121 FPHLIVSNKA QLEADEYFVW NYNPRTYMDY LIVIGVVSII LALVCYPLWP RSMRRGSYYV 180
  181 SLGAFGILAG FFAVAILRLI LYVLSLIVYK DVGGFWIFPN LFEDCGVLES FKPLYGFGEK 240
  241 DTYSYKKKLK RMKKKQAKRE SNKKKAINEK AEQN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SEC62 SEC63 SEC66 SEC72
    View Details (MIPS) Mewes HW, et al. (2004) SEC62 SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2006) SEC62 SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2002) ANP1 FKS1 MNN10 SEC62 SEC63 SEC66 SEC72
    View Details Qiu et al. (2008) SBH1 SEC61 SEC62 SEC63 SEC66 SEC72 SRP102 SSH1 SSS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC62 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] MSA 1.018988 View MSA. No confident structure predictions are available.
    2 View Details [106..274] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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