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The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. The process of directing proteins towards a membrane, usually using signals contained within the protein. The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: cotranslational protein targeting to membrane
Acc: GO:0006613
Aspect: Biological Process
Desc: The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria.
Synonyms:
  • cotranslational membrane targeting
  • cotranslational protein membrane targeting
  • cotranslational protein-membrane targeting
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 126 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006613 - cotranslational protein targeting to membrane (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle