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Protein Overview: BUD2

General Information:
Name(s) found: BUD2 / YKL092C [SGD]
Description(s) found:
Found 29 descriptions.
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  • GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1104 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: filamentous growth [IMPLink to PubMed article]
    axial cellular bud site selection [TASLink to PubMed articleLink to PubMed article]
    cellular bud site selection [TASLink to PubMed article]
    bipolar cellular bud site selection [TASLink to PubMed articleLink to PubMed article]
    small GTPase mediated signal transduction [TASLink to PubMed article]
    Molecular Function: GTPase activator activity [TASLink to PubMed articleLink to PubMed article]
    Ras GTPase activator activity [TASLink to PubMed article]
    signal transducer activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNEPAQS RTSYFKLNEF LSNVKHYKNT FKGEIQWCNN LSLNDWKTHY LQITSTGALT  60
   61 HSIDELTADS TNIQPIIKHL QQCRIEIIKD KHSSFKDINA NCNFIIQVNT SGKDNKVYLR 120
  121 VKSWSDFKKL LTCLIWWSSM KTNGIFNKFQ VSRPLEFKSK KMAKPESLLV YKLNVFGPIV 180
  181 KNIVLPPATN ILESPDIINN DDNSVGWFSA MGVLKSNGML DLLLQSDGSL IYSLNISQLL 240
  241 RSEIRILDSS VLQSENSLFL GELPLLRSQL GLEKFRIENI ASAATNSSDI SQEIIVEFPL 300
  301 RIDLEDCFIA LQSFARSEYL SITGSDKSND MKISNSFKIS ILEANFQSIN LNDKNNTPWS 360
  361 IFTDITAWGH TWARTSMVSN SSNPFWREEF QFNELLRLTN SYLEIKQLFH DLNNKKRLRL 420
  421 IGKIKITQEI INDTRYNKET RLPIMDVDNK NFQIGTICIK ISSNLNFILP STNFVKLEKL 480
  481 LMNANLSMVS NLIYKSSSSM ENDNKLTQTS IIFLDIFQSL SRIEEWFHVL IDKELAKIDG 540
  541 TVSRINQKNL DSKHVFNSLF RGNSILTKSI EQYFFRVGNE YLSKALSAIL KEIIESNKSC 600
  601 ELDPARVKEK DEVKKRKIIA DNYKRLYSWV TKIWKRLYAT SNDLPIEIRN VLKIFRQKLE 660
  661 IICIDDTLQI ILNGISGLLF LRFFCPVILN PKLFKYVSQN LNETARRNLT LISKVLLNLS 720
  721 TLTQFANKEP WLMKMNNFID KRHNDLLDYI DKMTQKKLDF NSKILNLSST ISRPKLAIEQ 780
  781 TMLDDLPQIP YLLDKNLRET EFVNLIVNFS QEDMTKMEKY NHMDNGGKGE LIEEEGLLSG 840
  841 SSLNLSVDKK DLDSPIEVKP EIGELEFEKI TENNTEIFGD DLMNLLKSDD VGSRSRDLDN 900
  901 GANSGIKFNS IIPKAEEEKH AMKELEQESC LLYNRINHIR KRLSGYECAS STLFEDKKYS 960
  961 ISLSHKIFYE EIKEGKEIVL KLLNKPTNEN SSARLQKFFT KGVSSKSNNT VGDSYCKFLT1020
 1021 IDVSDENPKS SNKTSVHGTS SENGAKDDYL TLPNSQGKGN LGNRFSPTKL SRIMRKPPNA1080
 1081 DVPKEQNSRK LTRWFKKKKE TGGS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUD2 MBP1 MSA2 SWI4 SWI6 WHI5
    View Details Gavin AC, et al. (2006) BUD2 CCP1 MRP8 PDR5 PET9 PTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUD2 PRM5 2 Unpublished Fields Lab Data
    View Screen BUD2 EEB1 2 Unpublished Fields Lab Data
    View Screen BUD2 CLN2 2 Drees BL, et al. (2001)
    View Screen ARF3 BUD2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BUD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] deduced N/A No confident structure predictions are available.
    2 View Details [195..316] PSI-BLAST 59.522879 Synaptogamin I
    3 View Details [317..466] PSI-BLAST 59.522879 Synaptogamin I
    4 View Details [467..535]
    [759..827]    		 PSI-BLAST 271.68867 p120GAP domain
    5 View Details [536..758] PSI-BLAST 271.68867 p120GAP domain
    6 View Details [828..1104] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.23789256375467 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.21562004568462 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.91645234075732 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.81440293338491 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.76400460221691 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.5322075775333 bayes_pls_golite062009
  • enzyme activator activity
    		•  4.29367232260052 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.29568423512865 bayes_pls_golite062009
  • binding
    		•  1.62780792681766 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • GTPase binding
    		•  0.240141218420366 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0713778754122761 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle