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Protein Overview: SWI6

General Information:
Name(s) found: SWI6 / YLR182W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 803 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: transcription [TASLink to PubMed article]
    regulation of transcription involved in G1/S-phase of mitotic cell cycle [TASLink to PubMed article]
    meiosis [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    transcription coactivator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEEVVRYL GPHNEIPLTL TRDSETGHFL LKHFLPILQQ YHDTGNINET NPDSFPTDEE  60
   61 RNKLLAHYGI AVNTDDRGEL WIELEKCLQL LNMLNLFGLF QDAFEFEEPE TDQDEEDPSH 120
  121 SKLPENKTKS ENSKDNISSK RINNLQDMSL DSDAHRELGS PLKKLKIDTS VIDAESDSTP 180
  181 NTARGKPNDD INKGPSGDNE NNGTDDNDRT AGPIITFTHD LTSDFLSSPL KIMKALPSPV 240
  241 VNDNEQKMKL EAFLQRLLFP EIQEMPTSLN NDSSNRNSEG GSSNQQQQHV SFDSLLQEVN 300
  301 DAFPNTQLNL NIPVDEHGNT PLHWLTSIAN LELVKHLVKH GSNRLYGDNM GESCLVKAVK 360
  361 SVNNYDSGTF EALLDYLYPC LILEDSMNRT ILHHIIITSG MTGCSAAAKY YLDILMGWIV 420
  421 KKQNRPIQSG TNEKESKPND KNGERKDSIL ENLDLKWIIA NMLNAQDSNG DTCLNIAARL 480
  481 GNISIVDALL DYGADPFIAN KSGLRPVDFG AGTSKLQNTN GGDENSKMVS KGDYDGQKNG 540
  541 KAKKIRSQLL KNPPETTSLI NDVQNLLNSI SKDYENETVQ YNEKLEKLHK ELNEQREELA 600
  601 NSREQLANVK QLKDEYSLMQ EQLTNLKAGI EEEEESFREE SKKLGIIADE SSGIDWDSSE 660
  661 YDADEPFKVE FLSDFLEDKL QKNYEGDISK LLEAESKEQI MEQIRNQLPA EKIQSMLPPT 720
  721 VLLKARINAY KRNDKHLTNV LDTISTKQSE LENKFRRVLS LCLKIDENKV DNMLDGLLQA 780
  781 ISSEDPQDID TDEMQDFLKK HAS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MBP1 SWI4 SWI6
    View Details (MIPS) Mewes HW, et al. (2004) MBP1 SWI4 SWI6
    View Details Krogan NJ, et al. (2006) BUD2 MBP1 MSA2 SWI4 SWI6 WHI5
    View Details Gavin AC, et al. (2006) SWI4 SWI6
    View Details Gavin AC, et al. (2002) MBP1 SWI6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SWI6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] MSA 1.285973 View MSA. No confident structure predictions are available.
    2 View Details [202..511] PSI-BLAST 10043.0 Swi6 ankyrin-repeat fragment
    3 View Details [512..600] PSI-BLAST 41.69897 bcl-3
    4 View Details [601..803] ORFEUS 8.12 Prolactin (placental lactogen)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • RNA binding
    		•  0.969928411729387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.0462605323512499 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • RNA binding
    		•  0.969928411729387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.0462605323512499 bayes_pls_golite062009
    4
    Term Confidence Notes
  • protein binding
    		•  3.32153200117175 bayes_pls_golite062009
  • binding
    		•  3.246345109977 bayes_pls_golite062009
  • receptor binding
    		•  2.75738439909781 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.27089567891838 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.13209989837612 bayes_pls_golite062009
  • cytokine activity
    		•  0.865612008604712 bayes_pls_golite062009
  • growth factor activity
    		•  0.805183150393473 bayes_pls_golite062009
  • catalytic activity
    		•  0.263255675478865 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle