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Protein Overview: MBP1

General Information:
Name(s) found: MBP1 / YDL056W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 833 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: DNA replication [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IMPLink to PubMed article][IPILink to PubMed article]
    transcription repressor activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNQIYSARY SGVDVYEFIH STGSIMKRKK DDWVNATHIL KAANFAKAKR TRILEKEVLK  60
   61 ETHEKVQGGF GKYQGTWVPL NIAKQLAEKF SVYDQLKPLF DFTQTDGSAS PPPAPKHHHA 120
  121 SKVDRKKAIR SASTSAIMET KRNNKKAEEN QFQSSKILGN PTAAPRKRGR PVGSTRGSRR 180
  181 KLGVNLQRSQ SDMGFPRPAI PNSSISTTQL PSIRSTMGPQ SPTLGILEEE RHDSRQQQPQ 240
  241 QNNSAQFKEI DLEDGLSSDV EPSQQLQQVF NQNTGFVPQQ QSSLIQTQQT ESMATSVSSS 300
  301 PSLPTSPGDF ADSNPFEERF PGGGTSPIIS MIPRYPVTSR PQTSDINDKV NKYLSKLVDY 360
  361 FISNEMKSNK SLPQVLLHPP PHSAPYIDAP IDPELHTAFH WACSMGNLPI AEALYEAGTS 420
  421 IRSTNSQGQT PLMRSSLFHN SYTRRTFPRI FQLLHETVFD IDSQSQTVIH HIVKRKSTTP 480
  481 SAVYYLDVVL SKIKDFSPQY RIELLLNTQD KNGDTALHIA SKNGDVVFFN TLVKMGALTT 540
  541 ISNKEGLTAN EIMNQQYEQM MIQNGTNQHV NSSNTDLNIH VNTNNIETKN DVNSMVIMSP 600
  601 VSPSDYITYP SQIATNISRN IPNVVNSMKQ MASIYNDLHE QHDNEIKSLQ KTLKSISKTK 660
  661 IQVSLKTLEV LKESSKDENG EAQTNDDFEI LSRLQEQNTK KLRKRLIRYK RLIKQKLEYR 720
  721 QTVLLNKLIE DETQATTNNT VEKDNNTLER LELAQELTML QLQRKNKLSS LVKKFEDNAK 780
  781 IHKYRRIIRE GTEMNIEEVD SSLDVILQTL IANNNKNKGA EQIITISNAN SHA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MBP1 SWI6
    View Details (MIPS) Mewes HW, et al. (2004) MBP1 SWI6
    View Details Krogan NJ, et al. (2006) BUD2 MBP1 MSA2 SWI4 SWI6 WHI5
    View Details Gavin AC, et al. (2002) MBP1 SWI6
    View Details Ho Y, et al. (2002) CDC28 CEG1 CKA1 CKA2 CKB1 CKB2 FKH1 FYV8 GCD2 GCD7 GCN3 HHF1, HHF2 HTB1 MBP1 MGM101 MPH1 NET1 NOP1 RRP1 SEC2 SIN3 SUI2 SUI3 UBP12 URE2 YGR017W YMR144W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MBP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 725.67837 DNA-binding domain of Mlu1-box binding protein MBP1
    2 View Details [132..305] MSA 1.274996 View MSA. No confident structure predictions are available.
    3 View Details [306..385] PSI-BLAST 21.69897 p18ink4C(ink6)
    4 View Details [386..555] PSI-BLAST 159.38764 Swi6 ankyrin-repeat fragment
    5 View Details [556..620] PSI-BLAST 13.0 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    6 View Details [621..833] MSA 2.342996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.36949648004482 bayes_pls_golite062009
  • DNA binding
    		•  4.06494205639151 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.98559547948274 bayes_pls_golite062009
  • transcription factor activity
    		•  3.87642218322379 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.19892138828988 bayes_pls_golite062009
  • binding
    		•  2.79149251200147 bayes_pls_golite062009
  • protein binding
    		•  1.55473080522232 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.838109968340069 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.68541709976608 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.576422771673579 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.4228431685549 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle