YRC Public Data Repository - Protein Structure Prediction

Protein:	MBP1
Organism:	Saccharomyces cerevisiae
Length:	833 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MBP1.

Description	E-value	Query Range	Subject Range
MBP1_YEAST - Transcription factor MBP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MBP1 PE=1 SV=1 MBP1 - Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a co...	0.0	[1..833]	[1..833]
MBP1_KLULA - Transcription factor MBP1 OS=Kluyveromyces lactis GN=MBP1 PE=4 SV=2 MBP1_KLULA - Transcription factor MBP1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 12...	0.0	[2..814]	[3..754]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[213..800]	[204..795]
gi\|3885972 - gi\|3885972\|gb\|AAC78143.1\| 270 kDa ankyrin G isoform [Rattus norvegicus]	2.0E-99	[123..800]	[127..803]
gi\|25121952, gi\|... - gi\|25121952\|ref\|NP_733924.1\| ankyrin 3, epithelial isoform a [Mus musculus], gi\|18203774\|gb\|AAH21657...	2.0E-98	[213..800]	[187..778]
ANK2 - ankyrin 2, neuronal	2.0E-94	[246..795]	[233..788]

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Predicted Domain #1

Region A:
Residues: [1-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNQIYSARY SGVDVYEFIH STGSIMKRKK DDWVNATHIL KAANFAKAKR TRILEKEVLK  60
   61 ETHEKVQGGF GKYQGTWVPL NIAKQLAEKF SVYDQLKPLF DFTQTDGSAS PPPAPKHHHA 120
  121 SKVDRKKAIR S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	725.67837
Match:	1mb1__
Description:	DNA-binding domain of Mlu1-box binding protein MBP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.36949648004482	bayes_pls_golite062009
DNA binding	4.06494205639151	bayes_pls_golite062009
nucleic acid binding	3.98559547948274	bayes_pls_golite062009
transcription factor activity	3.87642218322379	bayes_pls_golite062009
sequence-specific DNA binding	3.19892138828988	bayes_pls_golite062009
binding	2.79149251200147	bayes_pls_golite062009
protein binding	1.55473080522232	bayes_pls_golite062009
transcription repressor activity	0.838109968340069	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [132-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTSAIMETK RNNKKAEENQ FQSSKILGNP TAAPRKRGRP VGSTRGSRRK LGVNLQRSQS  60
   61 DMGFPRPAIP NSSISTTQLP SIRSTMGPQS PTLGILEEER HDSRQQQPQQ NNSAQFKEID 120
  121 LEDGLSSDVE PSQQLQQVFN QNTGFVPQQQ SSLIQTQQTE SMATSVSSSP SLPT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [306-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPGDFADSNP FEERFPGGGT SPIISMIPRY PVTSRPQTSD INDKVNKYLS KLVDYFISNE  60
   61 MKSNKSLPQV LLHPPPHSAP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.69897
Match:	1bu9A_
Description:	p18ink4C(ink6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	2.69918165732603	bayes_pls_golite062009
binding	2.60916417202222	bayes_pls_golite062009
transcription regulator activity	2.37103377984038	bayes_pls_golite062009
nucleic acid binding	1.8957142857582	bayes_pls_golite062009
DNA binding	1.78305438715057	bayes_pls_golite062009
transcription activator activity	1.6418915400902	bayes_pls_golite062009
transcription factor activity	1.2667825651547	bayes_pls_golite062009
transcription factor binding	1.06366405671195	bayes_pls_golite062009
sequence-specific DNA binding	0.949906091645366	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	0.68541709976608	bayes_pls_golite062009
protein kinase regulator activity	0.576422771673579	bayes_pls_golite062009
kinase regulator activity	0.4228431685549	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [386-555]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIDAPIDPEL HTAFHWACSM GNLPIAEALY EAGTSIRSTN SQGQTPLMRS SLFHNSYTRR  60
   61 TFPRIFQLLH ETVFDIDSQS QTVIHHIVKR KSTTPSAVYY LDVVLSKIKD FSPQYRIELL 120
  121 LNTQDKNGDT ALHIASKNGD VVFFNTLVKM GALTTISNKE GLTANEIMNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	159.38764
Match:	1sw6A_
Description:	Swi6 ankyrin-repeat fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [556-620]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYEQMMIQNG TNQHVNSSNT DLNIHVNTNN IETKNDVNSM VIMSPVSPSD YITYPSQIAT  60
   61 NISRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.0
Match:	1dcqA_
Description:	Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [621-833]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPNVVNSMKQ MASIYNDLHE QHDNEIKSLQ KTLKSISKTK IQVSLKTLEV LKESSKDENG  60
   61 EAQTNDDFEI LSRLQEQNTK KLRKRLIRYK RLIKQKLEYR QTVLLNKLIE DETQATTNNT 120
  121 VEKDNNTLER LELAQELTML QLQRKNKLSS LVKKFEDNAK IHKYRRIIRE GTEMNIEEVD 180
  181 SSLDVILQTL IANNNKNKGA EQIITISNAN SHA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: