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Protein Overview: GCD2

General Information:
Name(s) found: GCD2 / YGR083C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 651 amino acids

    Gene Ontology:
    Cellular Component: guanyl-nucleotide exchange factor complex [IDALink to PubMed article][IGILink to PubMed article]
    eukaryotic translation initiation factor 2B complex [IDALink to PubMed article][IGILink to PubMed article][IPILink to PubMed article]
    Biological Process: regulation of translational initiation [IDALink to PubMed article][IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: translation initiation factor activity [IGILink to PubMed article][IMPLink to PubMed article]
    guanyl-nucleotide exchange factor activity [IDALink to PubMed article]
    enzyme regulator activity [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESEAKSRS ATPPSKAKQA TPTTTAAANG EKKLTNKELK ELKKQEKAAK RAAMKQANGI  60
   61 SIEQQQQQAQ MKKEKKQLQR EQQQKREQKQ KNANKKKQNE RNVKKSTLFG HLETTEERRA 120
  121 TILALTSAVS SPKTSRITAA GLMVPVVASA LSGSNVLTAS SLMPVGPNAS STVSASAPAS 180
  181 TTTTLPASSA ALSAGTSSAS TNTPTAIQQE IASSNASDVA KTLASISLEA GEFNVIPGIS 240
  241 SVIPTVLEQS FDNSSLISSV KELLLNKDLI HPSILLLTSH LAHYKIVGSI PRCIAMLEVF 300
  301 QIVIKDYQTP KGTTLSRNLT SYLSHQIDLL KKARPLSVTM GNAIRWLKQE ISLIDPSTPD 360
  361 KAAKKDLCEK IGQFAKEKIE LADQLIIDNA STQIEESTTI VTYGSSKVLT ELLLHNAISL 420
  421 KKNIKVIVVD SRPLFEGRKM AETLRNAGVN VMYALITSLD TIFNMDVDYV FLGAHSILSN 480
  481 GFLYSRAGTA MLAMSAKRRN IPVLVCCESL KFSQRVQLDS VTFNELADPN DLVNIDYENP 540
  541 VERRGNKGAL LNQFIKERKF EKKKLAMENK PKGNKIGGKK GSEGESKDAS NEEDSNSKNI 600
  601 LDGWQELPSL NIVNILYDLT PPEYIKKVIT EFGALPPSSV PVILREYKGS A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 SUI2 SUI3
    View Details (MIPS) Mewes HW, et al. (2004) GCD1 GCD2 GCD6 GCD7 GCN3
    View Details Krogan NJ, et al. (2006) ADE1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 MRF1 MRH4 SUI2
    View Details Gavin AC, et al. (2006) GCD1 GCD11 GCD2 GCD6 GCD7 GCN3
    View Details Gavin AC, et al. (2002) CCT4 CHC1 COG8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GUT1 IST1 PDC1 PRO1 RRP40 RRP46 SUI2 SUI3 XKS1
    View Details Ho Y, et al. (2002) CDC28 CDC33 CEG1 CKA1 CKA2 CKB1 CKB2 FAA4 FAL1 FET3 FKH1 FYV8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 HHF1, HHF2 HTB1 LOS1 MBP1 MET18 MGM101 MPH1 NET1 NMD5 NOP1 PRO3 RRP1 SCW4 SEC2 SIN3 SUI2 SUI3 TIF1, TIF2 TIF4631 TIF4632 TUP1 UBP12 URE2 VAC8 VMA8 YGR017W YMR144W
    View Details Qiu et al. (2008) GCD1 GCD2 GCD6 GCD7 GCN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..354] PSI-BLAST 4.39794 Heavy meromyosin subfragment
    2 View Details [355..538] ORFEUS 9.43 D-ribose-5-phosphate isomerase (RpiA), catalytic domain; D-ribose-5-phosphate isomerase (RpiA), lid domain
    3 View Details [539..651] MSA 1.074992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.1099993541596 bayes_pls_golite062009
  • translation regulator activity
    		•  5.74669335554405 bayes_pls_golite062009
  • catalytic activity
    		•  1.31732715713197 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.30647139421574 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.09424756417577 bayes_pls_golite062009
  • binding
    		•  0.899200492696361 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.888163666064903 bayes_pls_golite062009
  • DNA binding
    		•  0.593071187541606 bayes_pls_golite062009
  • protein binding
    		•  0.0293610121675921 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0259936471063739 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle