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Protein Overview: ADE1

General Information:
Name(s) found: ADE1 / YAR015W [SGD]
Description(s) found:
Found 26 descriptions.
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  • N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 306 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: purine nucleotide biosynthetic process [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    'de novo' IMP biosynthetic process [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSITKTELDG ILPLVARGKV RDIYEVDAGT LLFVATDRIS AYDVIMENSI PEKGILLTKL  60
   61 SEFWFKFLSN DVRNHLVDIA PGKTIFDYLP AKLSEPKYKT QLEDRSLLVH KHKLIPLEVI 120
  121 VRGYITGSAW KEYVKTGTVH GLKQPQGLKE SQEFPEPIFT PSTKAEQGEH DENISPAQAA 180
  181 ELVGEDLSRR VAELAVKLYS KCKDYAKEKG IIIADTKFEF GIDEKTNEII LVDEVLTPDS 240
  241 SRFWNGASYK VGESQDSYDK QFLRDWLTAN KLNGVNGVKM PQDIVDRTRA KYIEAYETLT 300
  301 GSKWSH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 MRF1 MRH4 SUI2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ADE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..35]
    [78..110]    		 PSI-BLAST 1868.0 SAICAR synthase
    2 View Details [36..77]
    [111..306]    		 PSI-BLAST 1868.0 SAICAR synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
    		•  3.13563725397088 bayes_pls_golite062009
  • ligase activity
    		•  2.72434998554003 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.66954072457689 bayes_pls_golite062009
  • kinase activity
    		•  2.47933488612871 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.15276561572143 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.151446378007 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.8159520385203 bayes_pls_golite062009
  • binding
    		•  1.66593042987179 bayes_pls_golite062009
  • transferase activity
    		•  1.5866347320867 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  1.35725237917644 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.486217075920953 bayes_pls_golite062009
  • protein binding
    		•  0.382966234080422 bayes_pls_golite062009
  • protein kinase activity
    		•  0.135906673863896 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle