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View Structure Prediction Details

Protein: ADE1
Organism: Saccharomyces cerevisiae
Length: 306 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE1.

Description E-value Query
Range		 Subject
Range
ADE1 - N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purin...
gi|151941397 - gi|151941397|gb|EDN59768.1| SAICAR synthase [Saccharomyces cerevisiae YJM789]
gi|207347972 - gi|207347972|gb|EDZ73970.1| YAR015Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PUR7_YEAST - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Saccharomyces cerevisiae (strain ATCC 20...
gi|190406647 - gi|190406647|gb|EDV09914.1| phosphoribosyl amino imidazolesuccinocarbozamide synthetase [Saccharomyc...
 0.0 [1..306] [1..306]
PUR7_PICAN - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Pichia angusta GN=ADE1 PE=3 SV=1
PUR7_PICAN - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Pichia angusta GN=ADE1 PE=3 SV=1
 0.0 [1..305] [1..303]
PUR7_CYBJA - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Cyberlindnera jadinii GN=ADE1 PE=3 SV=1
 0.0 [1..304] [1..300]
PUR7_PICPA - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Komagataella pastoris GN=ADE1 PE=3 SV=1
 0.0 [1..305] [1..304]
ade7 - phosphoribosylamidoimidazolesuccinocarboxamide synthase Ade7
PUR7_SCHPO - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Schizosaccharomyces pombe (strain 972 / ...
 1.0E-99 [1..306] [1..299]
PUR7_CANMA - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Candida maltosa GN=ADE1 PE=3 SV=2
 3.0E-98 [3..304] [1..289]
PUR7_CANAX - Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Candida albicans GN=ADE1 PE=3 SV=1
 2.0E-97 [3..304] [1..289]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-97 [3..304] [1..289]

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Predicted Domain #1
Region A:
Residues: [1-35] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSITKTELDG ILPLVARGKV RDIYEVDAGT LLFVA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [78-110] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIAPGKTIFD YLPAKLSEPK YKTQLEDRSL LVH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1868.0
Match: 1a48__
Description: SAICAR synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity 3.13563725397088 bayes_pls_golite062009
ligase activity 2.72434998554003 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.66954072457689 bayes_pls_golite062009
kinase activity 2.47933488612871 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.15276561572143 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.151446378007 bayes_pls_golite062009
catalytic activity 1.87792712964225 bayes_pls_golite062009
acid-amino acid ligase activity 1.8159520385203 bayes_pls_golite062009
binding 1.66593042987179 bayes_pls_golite062009
transferase activity 1.5866347320867 bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity 1.35725237917644 bayes_pls_golite062009
lipid kinase activity 0.486217075920953 bayes_pls_golite062009
protein binding 0.382966234080422 bayes_pls_golite062009
protein kinase activity 0.135906673863896 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [36-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDRISAYDVI MENSIPEKGI LLTKLSEFWF KFLSNDVRNH LV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [111-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHKLIPLEVI VRGYITGSAW KEYVKTGTVH GLKQPQGLKE SQEFPEPIFT PSTKAEQGEH  60
   61 DENISPAQAA ELVGEDLSRR VAELAVKLYS KCKDYAKEKG IIIADTKFEF GIDEKTNEII 120
  121 LVDEVLTPDS SRFWNGASYK VGESQDSYDK QFLRDWLTAN KLNGVNGVKM PQDIVDRTRA 180
  181 KYIEAYETLT GSKWSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1868.0
Match: 1a48__
Description: SAICAR synthase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle