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View Structure Prediction Details

Protein: GCD2
Organism: Saccharomyces cerevisiae
Length: 651 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCD2.

Description E-value Query
Range
Subject
Range
GCD2 - Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for...
EI2BD_YEAST - Translation initiation factor eIF-2B subunit delta OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
gi|207345153 - gi|207345153|gb|EDZ72064.1| YGR083Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406897 - gi|190406897|gb|EDV10164.1| 71 kDa subunit [Saccharomyces cerevisiae RM11-1a]
0.0 [1..651] [1..651]
EI2BD_RAT - Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1
0.0 [49..574] [2..509]
gi|26986532, gi|... - gi|6012057|emb|CAB57304.1| guanine nucleotide exchange factor [Homo sapiens], gi|6010112|emb|CAB5726...
0.0 [49..574] [2..507]
EI2BD_MOUSE - Translation initiation factor eIF-2B subunit delta OS=Mus musculus GN=Eif2b4 PE=1 SV=2
1.0E-99 [49..574] [2..509]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-98 [57..574] [30..529]
gi|471329, gi|13... - gi|471329|emb|CAA53204.1| translation initiation factor eIF-2B-delta [Oryctolagus cuniculus], gi|130...
2.0E-98 [49..574] [6..512]

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Predicted Domain #1
Region A:
Residues: [1-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESEAKSRS ATPPSKAKQA TPTTTAAANG EKKLTNKELK ELKKQEKAAK RAAMKQANGI  60
   61 SIEQQQQQAQ MKKEKKQLQR EQQQKREQKQ KNANKKKQNE RNVKKSTLFG HLETTEERRA 120
  121 TILALTSAVS SPKTSRITAA GLMVPVVASA LSGSNVLTAS SLMPVGPNAS STVSASAPAS 180
  181 TTTTLPASSA ALSAGTSSAS TNTPTAIQQE IASSNASDVA KTLASISLEA GEFNVIPGIS 240
  241 SVIPTVLEQS FDNSSLISSV KELLLNKDLI HPSILLLTSH LAHYKIVGSI PRCIAMLEVF 300
  301 QIVIKDYQTP KGTTLSRNLT SYLSHQIDLL KKARPLSVTM GNAIRWLKQE ISLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [355-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPSTPDKAAK KDLCEKIGQF AKEKIELADQ LIIDNASTQI EESTTIVTYG SSKVLTELLL  60
   61 HNAISLKKNI KVIVVDSRPL FEGRKMAETL RNAGVNVMYA LITSLDTIFN MDVDYVFLGA 120
  121 HSILSNGFLY SRAGTAMLAM SAKRRNIPVL VCCESLKFSQ RVQLDSVTFN ELADPNDLVN 180
  181 IDYE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.43
Match: 1m0sA
Description: D-ribose-5-phosphate isomerase (RpiA), catalytic domain; D-ribose-5-phosphate isomerase (RpiA), lid domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.1099993541596 bayes_pls_golite062009
translation regulator activity 5.74669335554405 bayes_pls_golite062009
catalytic activity 1.31732715713197 bayes_pls_golite062009
nucleic acid binding 1.30647139421574 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.09424756417577 bayes_pls_golite062009
binding 0.899200492696361 bayes_pls_golite062009
transcription regulator activity 0.888163666064903 bayes_pls_golite062009
DNA binding 0.593071187541606 bayes_pls_golite062009
protein binding 0.0293610121675921 bayes_pls_golite062009
transcription factor activity 0.0259936471063739 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [539-651]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPVERRGNKG ALLNQFIKER KFEKKKLAME NKPKGNKIGG KKGSEGESKD ASNEEDSNSK  60
   61 NILDGWQELP SLNIVNILYD LTPPEYIKKV ITEFGALPPS SVPVILREYK GSA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle